Air pollution and alveolar health.

Exposure to air pollution has been associated with up to 9 million premature deaths per year worldwide, with the respiratory system a key site for its effects. Air pollution exposure is a well-established risk factor for the development and exacerbation of airways diseases and lung cancer, however relatively little is known regarding the risks associated with air pollution interacting with areas of gas exchange - the alveoli and pulmonary interstitium. In recent years, evidence has emerged identifying a role in the development and progression of sub-clinical interstitial lung abnormalities as well as progression and risk of exacerbation of fibrotic interstitial lung diseases.

Epilepsy Associated Gene, , Is Dispensable for Brain Development in Mice.

: Protocadherin 7 () belongs to the protocadherin family, the largest subgroup of cell adhesion molecules. Members of this family are highly expressed in the brain, where they serve fundamental roles in many neurodevelopmental processes, including axon guidance, dendrite self-avoidance, and synaptic formation. has been strongly associated with epilepsy in multiple genome-wide association studies (GWAS), as well as with schizophrenia, PTSD, and childhood aggression.

Targeting NRF2 and FSP1 to Overcome Ferroptosis Resistance in -Deficient and Cancer Cells.

: Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation and holds promise as a therapeutic strategy against cancers with elevated iron metabolism. However, many tumors evade ferroptosis through the upregulation of specialized antioxidant defense mechanisms. Here, we investigated ferroptosis susceptibility and resistance mechanisms in TSC models and in ovarian and breast cancer cell lines, aiming to identify potential therapeutic targets.

Thiamine Deficiency and Neuroinflammation Are Important Contributors to Alcohol Use Disorder.

Despite the growing morbidity associated with alcohol use disorder (AUD), current FDA-approved therapeutics fail to adequately address the condition. This is in part due to the complex systemic effects of ethanol (EtOH), which have particularly negative consequences on the gut-liver-brain axis. Importantly, two systemic mechanisms underlying the progression of AUD remain underemphasized in therapeutic development: thiamine deficiency and neuroinflammation.

Repair of a gluteal Morel-Lavallee lesion with complex perineal laceration in a 44-year-old female: a case report.

Morel-Lavallee lesions (MLL) are closed soft tissue degloving injuries that are primarily associated with high impact blunt trauma. The prognosis of MLL is dependent on a variety of factors, mainly severity and extent of other injuries. There is no current standard treatment protocol.