Mean Body Mass Index Does Not Increase or Decrease at 10 Years After Primary Total Hip or Knee Arthroplasty.

Background: Although patients often aim to lose weight after total hip arthroplasty (THA) or total knee arthroplasty (TKA), long-term changes in body mass index (BMI) are unknown. We analyzed BMI at 2, 5, and 10 years after primary THA and TKA and determined predictors of BMI change.

Methods: We identified patients who underwent primary THA or TKA for osteoarthritis between 2001 and 2011 and had a BMI at surgery and at 2, 5, and 10 years postoperatively.

Targeting dormant tumor cells to prevent recurrent breast cancer: a randomized phase 2 trial.

Breast cancer recurrence may arise from dormant disseminated tumor cells (DTCs) that persist in bone marrow and other sites. Clinically, DTCs are independently associated with breast cancer recurrence and death. Preclinical studies in mouse models identified autophagy and mammalian target of rapamycin (mTOR) signaling as critical mechanisms of tumor dormancy and escape.

Association Between the CEP72 Genotype and Chemotherapy-Induced Peripheral Neuropathy Severity in Young Adults Receiving Vincristine or Paclitaxel.

Objectives: To determine the relationship between chemotherapy-induced peripheral neuropathy (CIPN) severity and centrosomal protein 72 (CEP72) genotype in young adults receiving paclitaxel or vincristine.

Sample & Setting: 50 young adults aged 21-39 years who were expected to receive a cumulative dose of at least 7 mg vincristine or 700 mg/m2 paclitaxel for the treatment of cancer were recruited from Dana-Farber Cancer Institute.

Methods & Variables: Participants completed a CIPN assessment tool and provided a blood sample before the first infusion.

Leveraging data from commercial cattle for genetic improvement- an international perspective.

Genetic evaluations are predicated on routine access to large quantities of data on a range of performance traits from individual animals, their genetic relationships, as well as data on the factors other than additive genetic merit that influence phenotypic performance. Based on the well-established breeding pyramid, far more commercial animals generally exist relative to seedstock animals. Despite this, performance data from commercial animals is not always used in genetic evaluations.

Search for a Neutral Gauge Boson with Nonuniversal Fermion Couplings in Vector Boson Fusion Processes in Proton-Proton Collisions at sqrt[s]=13 TeV.

The first search for a heavy neutral spin-1 gauge boson (Z^{'}) with nonuniversal fermion couplings produced via vector boson fusion processes and decaying to tau leptons or W bosons is presented. The analysis is performed using LHC data at sqrt[s]=13  TeV, collected from 2016 to 2018 with the CMS experiment and corresponding to an integrated luminosity of 138  fb^{-1}. The data are consistent with the standard model predictions.