NINJ1 oligomerises on large apoptotic cell-derived extracellular vesicles to regulate vesicle stability and cellular content release.

Billions of cells undergo apoptosis, a non-inflammatory form of programmed cell death, daily as part of normal development and homeostasis. Apoptotic cells undergo apoptotic cell disassembly to release large extracellular vesicles (EVs) called apoptotic bodies (ApoBDs) to promote dead cell clearance, or otherwise proceed to an inflammatory, lytic outcome (i.e.

Skin capillary endothelial cells form a network of spatiotemporally conserved Ca activity.

Ca signaling and its regulation are important for endothelial cell (EC) functions, including local blood flow control, mechanotransduction, and barrier function. Yet the spatiotemporal organization of Ca activity and its regulation across a vascular plexus is poorly understood in an mammalian context, largely due to technical barriers. To overcome this gap in knowledge, we developed an approach to resolve Ca activity with single cell resolution in the skin vasculature of live adult mice by multi-photon imaging.

Deep phenotyping of a modified diabetic cardiomyopathy mouse model which reflects clinical disease progression.

Diabetic cardiomyopathy (DbCM) is a progressive disease and common complication of metabolic diabetes. It is characterised by onset of cardiac structural and functional impairments and can lead to direct development of clinical heart failure (HF) or predispose to hypertensive/ischaemic stress. DbCM is a complex disease which involves several metabolic and pathogenic factors.

Fibroblast depletion reveals mammalian epithelial resilience across neonatal and adult stages.

Regenerative organs, like the skin, depend on niche-stem cell interactions that sustain continuous cellular turnover. In cell culture, skin fibroblasts promote epidermal stem cell proliferation and differentiation. Yet, it remains elusive how fibroblasts regulate epidermal stem cell behaviors and differentiation .

Surgical application of a customised temporary palate guard to treat bleeding palatine ulcers in three cats.

Case Series Summary: Three adult cats were successfully treated for severe anaemia caused by a bleeding hard palate ulcer with a temporary palatal guard. Each cat required a blood transfusion and underwent surgical implantation of a customised temporary guard to protect the hard palate mucosa from ongoing irritation. The palatal guards were made from radiographic film in two cases and an acetate sheet in the third.