Cosolute-Induced Changes in the Properties, Water Dynamics, and Photophysics of Aqueous Triblock Copolymer Solutions.

In this perspective, we examine the cosolute-induced changes in the properties of the aqueous solution of block copolymers and their micellar characteristic. Owing to selective interactions of the cosolute with distinct domains of the block copolymer, alterations were observed in both the physical properties and water dynamics. However, the molecular mechanism of the cosolute in explaining its mechanistic properties is controversial.

Validation of blood phosphatidylethanol as an alcohol consumption biomarker in patients with alcohol use disorder and liver disease at a liver transplant center.

Background: Phosphatidylethanol (PEth), ethyl glucuronide (EtG), and ethyl sulphate (EtS) are highly sensitive and specific biomarkers of alcohol intake. This study investigated their application and relationship to traditional self-report measures in a mixed cohort of liver disease patients to guide decision making in liver transplant populations.

Methods: We recruited 183 participants (mean age 49.

When Light Tastes Sweet: Exclusive Sway of Glucose-Mediated Modulation of Excited-State Proton Transfer in Reverse Micelles.

We report the notable demonstration that glucose modulates excited-state proton transfer (ESPT) within reverse micelles formed by bis(2-ethylhexyl) sulfosuccinate sodium salt (AOT) and Igepal CO 520 (IGE). This study is significant because it uncovers how a simple, biologically relevant sweetener molecule, such as glucose, can influence proton transfer dynamics in confined water, offering insights into proton-coupled processes in biological and biomimetic systems. These findings offer broad chemical relevance for soft-matter chemistry and nanoscience.

Defining Risk in Alcohol-Associated Liver Disease Using the Model for End-Stage Liver Disease.

Introduction: Alcohol-associated liver disease (ALD) is a common cause of morbidity and premature mortality. Most prognostic scores have been defined in the short term. We used a large retrospective cohort of patients with ALD to describe the natural history of ALD and to define risk prediction in the longer term, taking nonliver mortality into account.

Photophysical Investigation of Styryl Dye in Ionic Liquid Micelles: Role of Micellar Polarity and Viscosity.

In the present work, we investigate the influence of micellar polarity and viscosity induced by ionic liquids (ILs) on the photophysical properties of the styryl dye 4-[4-(dimethylamino)styryl]pyridine (DMASP). Using combined absorption, fluorescence emission, time-resolved fluorescence spectroscopy, and density functional theory (DFT) calculations, we demonstrate that the photophysical behavior of DMASP is strongly affected by the polarity and viscosity of the IL environment. Temperature-dependent variations in the absorption and emission spectra further indicate that the photophysical properties of DMASP are strongly influenced by the viscosity of the micellar structures.