Publications by authors named "D Scott McVey"
African swine fever virus (ASFV) is one of the most significant viral pathogens affecting swine production worldwide. While several live attenuated ASF vaccines have been approved for clinical application in certain countries, there is a concern that the vaccine viruses might revert to virulence. Subunit vaccines containing one or a few viral immunogens provide a safer alternative.
View Article and Find Full Text PDFArticle Synopsis
- Bluetongue (BT) is a viral disease spread by midges, affecting deer and livestock, leading to major economic losses due to decreased animal production and trade restrictions.
- Researchers face challenges in studying this disease's transmission via live vectors, so they often use virus injections from baby hamster kidney (BHK) cells to induce infections in experimental models.
- A recent study found that using midge cell-derived BTV-17 resulted in more severe disease symptoms and higher mortality in mice compared to BHK cell-derived viruses, suggesting this method better mimics natural infections without the complications of working with live midges.
Article Synopsis
- Researchers studied how genetic factors influence the behavior of vascular smooth muscle cells (VSMCs) in processes like apoptosis, using samples from over 2000 individuals.
- While they found no significant links to VSMC proliferation or migration, two specific genetic loci were associated with increased VSMC apoptosis.
- The study highlighted the relationship between the genes GSDME and PALS2, suggesting that manipulating these genes could lead to new therapies targeting VSMC apoptosis.
Recent progress on gene-deleted live-attenuated African swine fever virus vaccines.
NPJ Vaccines
March 2024
African Swine Fever (ASF) is a highly lethal viral disease in swine, with mortality rates approaching 100%. The disease has spread to many swine-producing countries, leading to significant economic losses and adversely impacting global food security. Extensive efforts have been directed toward developing effective ASF vaccines.
View Article and Find Full Text PDFEvidence of Active Orbivirus Transmission in 2016 in Kansas and Nebraska.
Vector Borne Zoonotic Dis
June 2024
Retrospective serological and case diagnostic data of endemic bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV) provide evidence of viral transmission among livestock and wildlife from 2016 in Kansas and Nebraska. Serological testing of mature cattle in nine distinct regional zones of Kansas revealed 76% to 100% had detectable antibodies to BTV and/or EHDV. Specimens tested in the Kansas Veterinary Diagnostic Laboratory (55 submissions) were 51% test positive for antibodies to BTV and/or EHDV.
View Article and Find Full Text PDF