Visible Light-Induced, Persulfate-Promoted Synthesis of 2 Haloglycals from Glycals.

A visible light-driven, KSO-mediated one-step synthesis of 2-halo glycals has been reported, employing potassium salts as halogen source (KI, KBr, and KCl). Versatility of the proposed methodology to generate chloro-, bromo-, and iodo-substituted d-glycals containing both aliphatic and aromatic substitutions emphasizes the reproducibility of the methodology. The synthesized halogenated derivatives were subjected to Suzuki, Heck, and Sonogashira cross-coupling reactions, showcasing the utility of the halogenated derivatives for subsequent C-2 functionalization reactions of d-glycals.

Exploring potential biomarkers in foods of animal origin.

Biomarkers are important tools in almost every biological field, serving as means of understanding biological conditions, responses or processes. Although, applicability and importance of biomarkers in medicine and food are extensively studied and reported in literature, this review will emphasize on biomarkers associated with food and foods of animal origin like meat, fish, milk and egg. Evaluation of quality, safety and adulteration of food commodities is of the utmost importance with the ever-increasing global demand.

Structure and dynamics dictate the functional destiny of genomic DNA across multiple organisms.

DNA is a dynamic molecule composed of numerous genic and regulatory elements that orchestrate cellular functions. Traditional methods often fail to provide accurate functional genome annotations because they do not effectively account for sequence variability within and across different organisms. To address this, we conducted an extensive genomic physical fingerprinting of ~4.

Contemporary trends in targeted protein degradation for neurodegenerative diseases.

Neurodegenerative diseases (NDs), including Alzheimer's, Huntington's, and Parkinson's disease, are associated with significant declines in cognitive function and mobility. The accumulation of misfolded proteins such as β-amyloid, tau, α-synuclein, and polyglutamates is a key factor in the progression of these conditions. Unfortunately, traditional small-molecule drugs face major obstacles in effectively targeting these proteins.

Cancer of the cervix uteri: 2025 update.

Since the publication of the 2021 FIGO Cancer Report, there has been further progress in the global effort to attain the WHO goal of cervical cancer elimination using a three-pillar approach of vaccination, screening, and treatment. The HPV vaccination is now included in the national program of over 140 countries. Two-dose schedules are being implemented in 80 countries and one-dose schedules in 60 countries.