Tree-Ring and Sediment Analyses Reveal Processes of Bald Cypress Ghost Forest Formation From Dredging in the Cape Fear River, North Carolina, USA.

Forested, freshwater tidal wetlands in the southeastern US are dominated by bald cypresses (), which tolerate low levels of salinity. However, the response of old-growth bald cypress trees to prolonged increases in salinity remains uncertain. Bald cypress ghost forests occur along Smith Creek, a tributary of the Cape Fear River, North Carolina which has been dredged multiple times since 1871.

Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents.

C-C chemokine receptor type 5 (CCR5) antagonists may improve both acute stroke outcome and long-term recovery. Despite their evaluation in ongoing clinical trials, gaps remain in the evidence supporting their use. With a panel of patients with lived experiences of stroke, we performed a systematic review of animal models of stroke that administered a CCR5 antagonist and assessed infarct size or behavioural outcomes.

Evaluating sensitivity and specificity of the DPP Vet TB assay in badgers using Bayesian latent class models.

In the UK and Ireland, the European badger is the main wildlife reservoir for Mycobacterium bovis (M. bovis), the causal agent of bovine tuberculosis (bTB). The ability to diagnose M.

Post-Stroke Recovery in Relation to Parvalbumin-Positive Interneurons and Perineuronal Nets.

Background: There is a critical time window of post-stroke neuroplasticity when spontaneous behavioral recovery occurs. Potential factors responsible for this heightened plasticity are the reduction of parvalbumin-immunoreactive (PV+) interneuron inhibitory signaling and the disappearance of extracellular matrix synaptic stabilizers called perineuronal net(s; PNN/PNNs).

Objective: This study investigated whether behavioral recovery during this critical period following stroke is associated with changes in densities of PV+ interneurons and PNNs.

Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration.

Introduction: Bacterial infection of the intervertebral disc can lead to vertebral endplate edema known as Modic changes, with associated chronic low back pain. Oral antimicrobial therapy has shown efficacy but relies on prolonged dosing and may not be optimal in terms of patient outcome, side effects, or antibiotic stewardship. There is no antibiotic formulation approved for intradiscal administration.