Deposition of metal-organic frameworks within a porous protein crystal superstructure.

Metal-organic frameworks (MOFs) exhibit promising catalytic properties for applications in environmental cleansing, drug delivery, and chemical warfare agent detoxification. However, their broad adoption is hindered by poor structural stability in biologically relevant (aqueous) conditions. Protein crystals, by contrast, offer exceptional environmental resilience, particularly in aqueous and intracellular environments.

Polyphosphate discriminates protein conformational ensembles more efficiently than DNA promoting diverse assembly and maturation behaviors.

Disordered proteins and domains often assemble into condensates with polyanionic nucleic acids, primarily via charge complementarity, regulating numerous cellular functions. However, the assembly mechanisms associated with the other abundant and ubiquitous, anionic, stress-response regulating polymer, polyphosphate (polyP), are less understood. Here, we employ the intrinsically disordered DNA-binding domain (DBD) of cytidine repressor (CytR) from to study the nature of assembly processes with polyP and DNA.

Comprehensive Characterization and Biological and Safety Evaluation of Zinc Oxide-Curcumin Nanoconjugates: Unraveling Synergistic Effects for Enhanced Therapeutic Applications.

Nanoparticles have been widely synthesized and used in various biological applications. Among the minerals, zinc (Zn) alters numerous biological pathways, and curcumin (Cur) functions mainly as the antimicrobial, anti-inflammatory, and anticancerous agent. In this study, nano-zinc oxide (nZnO), nano-curcumin (nCur), and its conjugate (nZnOcur) were synthesized through the chemical reduction method.

In silico analysis of Triphala-derived polyphenols as inhibitors of TIR-TIR homodimerization in the inflammatory pathway.

Downstream signaling of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway is mediated by the adaptor protein myeloid differentiation primary response gene 88 (). The TIR domain present in plays a pivotal role in regulating the expression of pro-inflammatory cytokines. Although synthetic drugs, including M20 and TJ-M2010-5, have been studied to mitigate the overexpression of , their prolonged usage is known to cause adverse side effects, highlighting the need for a safer, risk-free alternative.