Updated global distribution of Plasmodium vivax circumsporozoite protein variants and their correlation with vector susceptibility: A systematic review and meta-analysis.

The global distribution of Plasmodium vivax Circumsporozoite Protein variants (PvCSP), VK210, VK247, and P. vivax-like, plays a crucial role in malaria transmission and vaccine development. This systematic review and meta-analysis assessed the prevalence of these variants in humans and their association with Anopheles species worldwide.

Acute Rickettsiosis Triggering Relapse in a Returned Traveler: A Case Report and Clinical Review of Travel-Related Coinfections.

Given the overlap of epidemiological and clinical presentations of both rickettsioses and malaria infections, diagnostic testing where malaria is confirmed or excluded, without subsequent rickettsial testing, specifically in the case of or infection, may mask the possibility of relapse. A lack of clinical suspicion of co-infections, absence of knowledge on the geographic distribution of diseases, and lack of availability of point-of-care diagnostic testing for other tropical diseases can often lead to missed diagnosis or misdiagnosis of common tropical infections, including rickettsioses. We herein describe a case of confirmed intercurrent rickettsial and infection, with the former potentially triggering a relapse of the latter in a febrile traveler returning to Canada from South America, and review the literature on tropical coinfections in returning travelers.

Real-world persistence of bictegravir versus dolutegravir single-tablet regimens: A retrospective cohort study in a large urban Canadian HIV clinic.

BackgroundSingle-tablet regimens (STRs) with integrase inhibitors, bictegravir (BIC) or dolutegravir (DTG), are favored in HIV treatment for their efficacy and convenience. This study compares persistence-time from initiation to discontinuation-between BIC/emtricitabine (FTC)/tenofovir alafenamide (TAF) and DTG-containing STRs at a Toronto HIV clinicMethodsA retrospective cohort analysis was conducted on 1732 adults with HIV at Maple Leaf Medical Clinic who initiated or switched to BIC/FTC/TAF or DTG-containing STRs from 2016 to 2022. Persistence was measured in days until discontinuation.

A Novel Approach for Dengue Outbreak Prediction Using Evolutionary Sampling with Prediction Framework.

Background Objectives: The increasing prevalence of life-threatening viral diseases like dengue fever necessitates comprehensive research into their causes, recovery, and preventive measures. Dengue outbreak data often suffers from irregularities, underreporting, delays, and missing information, which challenge the development of reliable prediction models.

Methods: To overcome these issues, the study proposes an innovative framework that combines Evolutionary Sampling with Prediction (ESP) to handle temporal and stochastic dynamics, along with a Minimax K-nearest neighbour imputer to correct missing data biases.

Stabilizing Carbonic Anhydrase at Elevated Temperatures via Amine-Functionalized Boron Nitride Nanosheets.

Capturing carbon dioxide (CO) remains a critical challenge in mitigating climate change due to its stability and low reactivity. Carbonic anhydrase (CA), a highly efficient enzyme capable of converting CO to bicarbonate at a turnover rate of up to 1 × 10 s, presents a promising solution for carbon capture and storage (CCS). However, its industrial application is limited by poor thermal and chemical stability, especially under harsh conditions such as those found in flue gas streams.