Enantioselective Pd-Catalysed Nucleophilic C(sp)-H (Radio)fluorination.

Despite increasing demand for chiral fluorinated organic molecules, enantioselective C-H fluorination remains among the most challenging and sought-after transformations in organic synthesis. Furthermore, utilizing nucleophilic sources of fluorine is especially desirable for F-radiolabelling. To date, methods for enantioselective nucleophilic fluorination of inert C(sp)-H bonds remain unknown.

Utilizing Lipid Bond Technology With Molecular Lipid Complex to Provide Lipid Treatment for Damaged Hair.

Human hair fibers are mainly composed of proteins, lipids, and water. In particular, lipids play an important role in keeping hair healthy, stabilizing its structure, affecting shine, feel, manageability, and strength. In addition to each person's physical condition and constitution, the cause of reduction and loss of hair lipids also comes from external causes such as UV, pollution, and specially styling chemicals.

Effects of Salinity, Temperature, and Diet on the Biological Characteristics of Müller, 1786.

This study investigates the effects of salinity, temperature, and diet on the biological characteristics of the rotifer , an essential live feed in aquaculture. The results indicate that environmental factors have a significant influence on reproductive traits and survival. At a salinity of 5 ppt, achieved the highest fecundity (25.

Bedaquiline, delamanid, linezolid, and clofazimine for rifampicin-resistant and fluoroquinolone-resistant tuberculosis (endTB-Q): an open-label, multicentre, stratified, non-inferiority, randomised, controlled, phase 3 trial.

Background: Pre-extensively drug-resistant (pre-XDR) tuberculosis (ie, multidrug-resistant or rifampicin-resistant with additional resistance to any fluoroquinolone) is difficult to treat. endTB-Q aimed to evaluate the efficacy and safety of bedaquiline, delamanid, linezolid, and clofazimine (BDLC) compared with the standard of care for patients with pre-XDR tuberculosis.

Methods: This open-label, multicentre, stratified, non-inferiority, randomised, controlled, phase 3 trial was conducted in ten hospitals in India, Kazakhstan, Lesotho, Pakistan, Peru, and Viet Nam.

A rare unusual location of neuroblastoma in theanterior-middle mediastinum in infant: A case report and literature review.

Neuroblastoma is a common tumor in children; however, its occurrence in the mediastinum - particularly in the anterior-middle mediastinum - is rare. Early diagnosis is crucial to initiate timely treatment and prevent disease progression. Surgery and chemotherapy are the standard treatments for neuroblastoma.