Combination of hydroxycitric acid and capsaicin regulates IRS-1/AMPK-mTOR-SREBP-1c Axis/NLRP3-NF-κB/Nrf-2-ARE signaling pathways to ameliorate the two-hit process in high-fat diet-induced hepatic steatosis.

Metabolic (Dysfunction) Associated Steatotic Liver Disease (MASLD) is a complex metabolic condition, the progression of which toward steatohepatitis can be explained by the 'two-hit' hypothesis: the first hit involves lipid accumulation, and the second hit involves inflammation and oxidative stress. In this study, we aimed to evaluate the protective effects of a combination of hydroxycitric acid and capsaicin (CHC) against high-fat diet (HFD)-induced MASLD in rats, specifically by targeting the mechanisms associated with both hits. To establish the experimental model, rats were fed a HFD for 16 weeks, followed by treatment with CHC for 6 weeks starting on day one of the 16th week of HFD feeding.

Haemophagocytic lymphohistiocytosis triggered by Rickettsia conorii.

Haemophagocytic lymphohistiocytosis (HLH) is a rare complication of rickettsial infections. We report a 50-y-old man from northern India who presented with fever, respiratory distress, altered sensorium and an eschar. Despite treatment with doxycycline, his condition deteriorated with multi-organ dysfunction.

Multifunctional reconfigurable reflective metasurface for polarization conversion.

Multifunctional and reconfigurable metasurfaces are increasingly important as they facilitate the dynamic manipulation of electromagnetic waves, enabling adaptive responses to varying communication requirements and environmental conditions-a characteristic feature of 6G networks. This paper presents a design for a multifunctional reconfigurable metasurface that can convert linearly polarized (LP) electromagnetic waves to their orthogonal (OLP) counterparts in frequency band-1 (4.85 to 6.

Histopathological image based breast cancer diagnosis using deep learning and bio inspired optimization.

Breast cancer diagnosis remains a crucial challenge in medical research, necessitating accurate and automated detection methods. This study introduces an advanced deep learning framework for histopathological image classification, integrating AlexNet and Gated Recurrent Unit (GRU) networks, optimized using the Hippopotamus Optimization Algorithm (HOA). Initially, DenseNet-41 extracts intricate spatial features from histopathological images.

Effect of Ultraviolet Photofunctionalization of Titanium Dental Implants on the Stability, Osseointegration Speed and Crestal Bone Loss in Controlled Diabetic Patients: A Split Mouth Randomized Clinical Trial.

Our objective was to evaluate and compare the effects of UV photofunctionalized (UVP) dental implants on implant stability, osseointegration, and radiographical bone changes with non-UV photofunctionalized (NUVP) dental implants placed in controlled diabetics. Participants were selected using stratified random sampling to ensure proportional representation of age groups, gender, and other relevant subgroups within the controlled diabetic population. The sites were randomly allocated into UVP and NUVP groups.