Microenvironment-Driven Mast Cell Plasticity: Insights From Cytokine-Activated Gene Signatures in Skin and Respiratory Diseases.

Mast cells (MCs) rapidly adapt to the microenvironment due to the plethora of cytokine receptors expressed. Understanding microenvironment-primed immune responses is essential to elucidate the phenotypic/functional changes MCs undergo, and thus understand their contribution to diseases and predict the most effective therapeutic strategies. We exposed primary human MCs to cytokines mimicking a T1/pro-inflammatory (IFNγ), T2/allergic (IL-4 + IL-13), alarmin-rich (IL-33) and pro-fibrotic/pro-tolerogenic (TGFβ) microenvironment.

Laboratory-based syphilis lateral flow immunoassay testing for maternity care at Alice Springs Hospital: a pilot study.

Congenital syphilis is a preventable yet severe condition resulting from untreated maternal syphilis. Since 2016, Australia has recorded over 95 congenital syphilis cases, with 31/95 (33%) associated with perinatal death. Syphilis serology is complex and therefore performed in designated central laboratories.

Evaluation of Dexmedetomidine on Delirium in Elderly Patients Postoperatively: A Randomized Controlled Trial.

Introduction: Delirium, a common acute brain dysfunction in older adults, features rapid changes in attention, awareness, and thinking that fluctuate. It presents diversely with altered activity levels and sleep. Postoperative delirium (POD), often seen in the postanesthesia care unit, is a temporary mental status change, with hypoactivity being common.

MiRNA Regulations in Cardiotoxicity Induced by Oncologic Therapies and Possible Immune Response.

Anti-cancer therapy offers significant risks for cardiovascular diseases, including hypertension, thromboembolic ischaemia, arrhythmias, dyslipidaemia, hyperglycemia, obesity, and high cholesterol. Cardiotoxicity is a leading cause of elevated mortality rates among cancer patients, and anti-cancer drugs often contribute to this issue. Emerging research highlights the role of microRNA (miRNAs) in regulating drug-induced cardiotoxicity by influencing genetic, epigenetic, transcriptional, and translational processes.

Catechol 2,3-dioxygenase isoenzymes from Diaphorabacter sp. strain DS2 demonstrate different substrate preferences.

Two monomeric isozymes of catechol 2,3-dioxygenase C23O64 and C23O68 (EC 1.13.11.