Multimorbidity burden predicts lower likelihood of remission and higher likelihood of disease flare in patients with rheumatoid arthritis.

Objectives: To examine associations between multimorbidity, the social determinants of health (SDoHs) and rheumatoid arthritis (RA) flare and remission.

Methods: All patients aged ≥18 years in Olmsted County, Minnesota, with incident RA in 1999-2014 were identified. Using a list of 55 chronic medical conditions, multimorbidity was defined as the presence of ≥2 conditions and substantial multimorbidity as ≥5 conditions.

Developing efficient predictive models for the diagnosis of VEXAS syndrome.

Objectives: To identify clinical and laboratory features associated with the presence of UBA1 mutation and develop predictive models to guide efficient diagnosis of VEXAS syndrome.

Methods: All patients who underwent UBA1 mutation testing were identified. Using a comprehensive list of VEXAS syndrome features, the presence or absence of each feature in each patient was determined for two timepoints: time of first VEXAS symptom onset and the time of UBA1 mutation testing.

Outcomes of CT-Guided Targeted Epidural Patching For Lateral Dural Tears In Spontaneous Intracranial Hypotension: A Multicenter Retrospective Cohort Study.

Background And Purpose: Spontaneous intracranial hypotension (SIH) due to lateral dural tears with spinal longitudinal extradural fluid collections (SLECs) can cause disabling orthostatic headaches. While epidural patching is commonly used as first-line treatment, outcomes specific to lateral dural tears have not been well characterized. We aimed to evaluate clinical and radiologic outcomes following CT-guided patching for lateral dural tears and assess whether anatomic or procedural factors- including presence of a herniated arachnoid pouch, patch volume, material, or approach-influence treatment success.

Valorization Pathway for Grape Pruning and Pomace Waste from the Wine Industry: Energy and Non-Energy Applications.

Wine is a popular beverage worldwide, and its consumption continues to rise, leading to waste, particularly from vine prunings and grape pomace. The aim of this study was to create a valorization pathway utilizing these waste materials. To achieve this, proximate analysis, chemical composition, ultimate analysis, thermogravimetric analysis (TGA), and other physicochemical parameters for both vine prunings and grape pomace were assessed.