Ferulic acid suppresses Porphyromonas gingivalis biofilm formation via the inhibition of autoinducer-2 production and receptor activity.

Objective: This study aimed to clarify the antibacterial and antibiofilm effects of ferulic acid against periodontal pathogenic bacteria.

Design: The cytotoxicity of ferulic acid was examined using the MTT assay on the human oral epithelial cell line Ca9-22. To determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration, Porphyromonas gingivalis ATCC 33277, Fusobacterium nucleatum ATCC 25586, Prevotella intermedia ATCC 25611, Aggregatibacter actinomycetemcomitans JP2, and Streptococcus mitis ATCC 903 were treated with ferulic acid.

Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action.

Treatments for tuberculosis remain lengthy, motivating a search for new drugs with novel mechanisms of action. However, it remains challenging to determine the direct targets of a drug and which disrupted cellular processes lead to bacterial killing. We developed a computational tool, DECIPHAER (decoding cross-modal information of pharmacologies via autoencoders), to select the important correlated transcriptional and morphological responses of Mycobacterium tuberculosis to treatment.

Two-stage wood decay by .

In nature, only white-rot fungi can completely decompose wood biomass in the environmental carbon cycle. However, their degradation strategy is still unclear. Despite many studies on the lab-scale wood-decay process, investigations on the open-field process have been limited by their difficulty.

A deep learning and digital archaeology approach for mosquito repellent discovery.

Insect-borne diseases kill > 0.5 million people annually. Currently available repellents for personal or household protection are limited in their efficacy, applicability, and safety profile.

Decreased Lactococcus lactis and Propionic Acid in Feces of Patients with Moyamoya Disease: Possible Implications of Immune Dysregulation.

Introduction: Moyamoya disease (MMD) is a cerebrovascular disease characterized by progressive steno-occlusive lesions in the terminal portion of the internal carotid artery. Despite its unknown etiology, immune dysregulation is regarded as a critical trigger for delineating the pathophysiology of MMD. The gut microbiota produces short-chain fatty (SCFA) and organic acids, influencing immune regulation and vascular remodeling.