International, Multi-Institutional Evaluation of Practice Patterns and Outcomes for Recurrent and Metastatic Sinonasal Undifferentiated Carcinoma.

Objectives: The aims of this study were to analyze the clinical characteristics of patients with recurrent and metastatic sinonasal undifferentiated carcinoma (SNUC) and evaluate the current treatment strategies to help guide future management.

Design: This is a retrospective cohort study.

Setting: The study was conducted at six international tertiary treatment centers.

Nasopharyngeal Endoscopic Resection Extended to the Internal Carotid Artery (Type 4): Technical Notes, Indications, and Outcomes.

Background: Endoscopic surgical approaches for nasopharyngeal malignancies, including recurrent nasopharyngeal carcinoma (rNPC) and nasopharyngeal salivary gland tumors (NSGT), have seen significant development over the last decades. Our groups have expanded the classification of nasopharyngeal endoscopic resections (NER) from type 1 to 3 to incorporate internal carotid artery (ICA)-including ablations. The aim of this work is to describe the surgical technique, indications, and preliminary oncological outcomes of NER extended to ICA, proposing it as type 4 NER.

The interplay of hypoxia, inflammation, and microbiota as indicators of malignant transformation in oral potentially malignant disorders.

Oral Potentially Malignant Disorders (OPMDs), such as leukoplakia, erythroplakia, proliferative verrucous leukoplakia, and oral submucous fibrosis, carry a risk of malignant transformation, with reported rates ranging from 2.6 % to 7.9 %.

Sinonasal intestinal-type adenocarcinoma: Multi-institutional retrospective analysis based on 440 patients with long-term follow-up.

Background: Sinonasal intestinal-type adenocarcinoma (ITAC) is the most common nasoethmoidal cancer in European countries. Subtypes and other prognostic factors/parameters are known to be associated with prognosis.

Methods: We performed a retrospective analysis of prognostic factors associated with overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS) in patients affected by histologically-proven sinonasal ITAC, managed with an endoscopic surgery-centered protocol in 6 European centers.

The role of volumetry in sinonasal cancer response assessment to induction chemotherapy, results from two phase II non-randomized controlled prospective multicentric trials: SINTART-1 and SINTART-2.

Objective: This study aims to identify the best response criteria in patients with sinonasal cancer undergoing induction chemotherapy (IC).

Material And Methods: Patients enrolled in SINTART-1 and SINTART-2 were included in this study. Unidimensional diameters (anteroposterior, AP; laterolateral, LL; craniocaudal, CC), maximum axial area (Amax), and volume (V) were performed on MRI by two radiologists.