Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode.

From single-cell extrusion to centimetre-sized wounds, epithelial gaps of various sizes and geometries appear across organisms. Their closure involves two orthogonal modes: lamellipodial crawling at convex edges and purse string-like movements at concave edges. The mechanisms driving this curvature-dependent migration remain unclear.

Evaluating the effectiveness of a novel cost-effective aerosol containment chamber for high-risk autopsies: a pilot study.

Autopsy personnel face substantial occupational risks from exposure to infectious agents, particularly during aerosol-generating procedures like bone sawing. The COVID-19 pandemic highlighted these dangers, underscoring the need for innovative safety solutions in resource-limited settings without negative-pressure autopsy suites. To address this, we developed a Low-Cost Infection Containment Chamber (LCICC)-a full-length, transparent, and impermeable structure designed to contain aerosols during high-risk autopsy procedures.

A comprehensive approach to child sexual abuse: Insights for dermatologists.

Child sexual abuse (CSA) is a serious public health issue in India, with long-lasting physical, emotional and psychological consequences. Dermatologists play a crucial, though often underappreciated, role in the identification and management of CSA due to expertise in recognising and interpreting cutaneous signs, which are the most common and visible indicators of abuse. The authors explore the pivotal role of dermatologists in the multidisciplinary approach to CSA, emphasising their involvement in history-taking, physical examination, injury interpretation, and forensic evidence collection.

Role of traditional and new biomarkers in the assessment of chronic kidney diseases: a comprehensive analysis of the biochemical, molecular and clinical dimensions.

Background: Kidney function is necessary for the diagnosis and treatment of renal diseases. Traditional biomarkers like creatinine have limitations due to their susceptibility to interference and fluctuation. This study's objective is to test and compare the efficacy of conventional and innovative biomarkers in evaluating kidney function and disease.

Utility of biomarkers in the postmortem diagnosis of fatal Anaphylaxis: A scoping review.

Background: Diagnosing anaphylactic deaths is a challenging task for forensic pathologists. Although serum tryptase is considered to be a reliable biomarker, there are limitations to it. Thus, there is an urgent need to explore various other potential biomarkers which could be of diagnostic value, along with Tryptase, to diagnose anaphylactic shock at autopsy.