Designing a 2000-Calorie Balanced Indian Diet for Diabetic Adults: Controlled Fat Intake and 50% Energy From Carbohydrates.

Setting:  The study was planned with the objective of developing a balanced diet menu based on Indian traditional food items, incorporating formatted fat and 50% of energy from carbohydrates, in line with general dietary recommendations. This was undertaken in the absence of any clear, viable, or India-specific menus or guidelines for constructing such a diet. The fat formatting, guided by metabolic expert recommendations and derived from routine/local foods, adds a unique aspect to the newly formulated menu.

Ring canals in the larval adipose of buffer stress response.

Cells in metabolically active tissues with high biosynthetic and secretory demands often use robust stress-responsive mechanisms to maintain endoplasmic reticulum (ER) homeostasis. Coordinating such robust stress response mechanisms requires intercellular communication and coordination. Such modalities of intercellular communication have been relatively understudied in the context of stress tolerance.

Emerging roles for integrated stress response signaling in homeostasis.

Across phyla, organisms have evolved signaling mechanisms to cope with cell-intrinsic and -extrinsic stressors. The integrated stress response (ISR) is a prime example of such a mechanism and has well-defined roles from yeast to humans in dealing with stress burdens imposed by nutrient deprivation, protein misfolding, infectious agents, and oxidative stress. As with many fundamental cellular processes, the complexity of ISR signaling increases with evolutionary complexity.

Study on external consistency of health management information system data at district level across India.

Background: The WHO has provided toolkit for data quality review of Health Management Information System (HMIS) data, with external consistency of coverage rate being one dimension.

Objective: To assess the level of external consistency of HMIS data compared with National Family Health Survey-5 (NFHS-5) data at district level across India.

Methods: We used secondary data on health service delivery indicators across districts at meso-level collected from HMIS and NFHS-5 website.

Comparison of analysis of serum free light chains in a cartridge-based protein analyzer Mispa i3 with Roche Cobas 8000.

Serum-free light-chain assays are important in the diagnosis and in monitoring therapeutic responses of plasma cell disorders and are complementary to serum protein electrophoresis. The serum-free light-chain assay detects the light-chain portion of immunoglobulin in its free form with high sensitivity. In combination with serum protein electrophoresis and serum immunofixation electrophoresis, the free light-chain assay serves an important role in predicting disease progression in monoclonal gammopathy.