Quality of Life, Disability, and Fungal Neglected Tropical Diseases.

Purpose Of Review: This review summarizes current literature about the disability burden of the fungal neglected tropical diseases (NTDs) sporotrichosis, chromoblastomycosis, eumycetoma, and paracoccidioidomycosis. The review highlights current knowledge gaps in global settings and describes available tools that could be adopted to fill these gaps.

Recent Findings: Sporotrichosis, chromoblastomycosis, and eumycetoma often present initially as skin lesions that can become progressively disfiguring, lead to stigmatization, and cause various sequalae affecting health and function.

Size and Shape Effects on Nanoparticle-Catalyzed Reactions Enabled by High-Throughput Variable-Temperature Desorption Electrospray Ionization Mass Spectrometry.

Nanoparticles exhibit unique catalytic properties that are highly dependent on their size and shape, influencing reaction rates, selectivity, and efficiency. Identifying the structural effects that achieve a high catalytic performance is critical to a wide range of applications, from energy conversion to environmental remediation. High-throughput screening (HTS) methods, particularly desorption electrospray ionization mass spectrometry (DESI-MS), offer a powerful approach for rapidly assessing the catalytic performance of nanoparticles with varying sizes and shapes.

Impact of charcoal production on soil micronutrients, enzyme activities, microbial composition, and biomass phosphorus in a derived savannah ecosystem of Nigeria.

Soil functions as the active force managing diverse biogeochemical processes in tropical forest ecosystems, including storing and recycling nutrients and decomposing organic matter. Anthropogenic activities, mainly deforestation on charcoal production, have substantially disrupted these processes, leading to notable changes in microbial activities, enzyme functions, and the availability and soil nutrient status of the derived savannah in southwestern Nigeria. While there is increasing recognition of charcoal's impact on soil properties, there remains a noticeable research gap in understanding its specific effects on some associated soil microbial properties, soil enzymes, and micronutrients in charcoal production sites.

Reduced recurrence of prostate cancer with novel autologous cancer vaccine (FK- PC101) post-prostatectomy: long-term results from a single-center phase 1/2 study.

Background: Prostate cancer is a major contributor to cancer-related mortality in men. High-risk patients, particularly those with biochemical recurrence (BCR) following radical prostatectomy (RP), face poor long-term outcomes. Adjuvant options such as radiotherapy, chemotherapy, and androgen deprivation therapy (ADT) have shown limited benefit in this setting.

Cytokine release syndrome in solid tumors.

Cytokine release syndrome (CRS) is a common and potentially severe complication of cancer immunotherapy, including CAR T-cell therapies, bispecific T-cell engagers, and less commonly immune checkpoint inhibitors. Although extensive research has established guidelines for managing CRS in hematological malignancies, there is a growing need to address CRS in the context of solid organ tumors due to differences in tumor microenvironment, immunotherapy indications, and patient population. This review aims to provide an overview of CRS in solid tumors, outlining its pathophysiology, clinical presentation, and current management strategies.