Genetic silencing of K3.1 inhibits atherosclerosis in ApoE null mice.

Increased expression of K3.1 has been found in vascular smooth muscle cells (SMC), macrophages, and T cells in atherosclerotic lesions from humans and mice. Pharmacological inhibition of K3.

Exploring the Protective Properties of Perceived Military and Non-Military Social Support in Relation to Perceived Substance Abuse Among Veterans With Chronic Pain.

Introduction: Perceived social support serves as a protective factor in the course of chronic pain and substance use disorders in civilian populations, but the role of support from civilians versus other military personnel for combat veterans experiencing chronic pain has not yet been explored. The current study examined differences in the protective properties of perceived social support from (1) military personnel and (2) civilians, regarding substance use and perceived substance abuse for combat veterans experiencing chronic pain. We hypothesized that higher endorsement of both types of perceived social support would be associated with lower odds of self-reported, perceived substance abuse, and support from military personnel would be associated with lower odds of perceived substance abuse after controlling for the role of non-military social support.

Novel electronic health records-based consultation workflow improves time to operating room for surgery patients in an acute setting.

Background: A novel electronic health records (EHR)-based workflow was implemented at a quaternary referral center to improve the efficiency of inpatient surgical consultation processes for patients requiring trauma or acute care surgery (TACS) consultation.

Methods: The EHR-driven consultation workflow automated notifications, communication of patient information, and data-tracking. Timeliness of care was compared between pre-implementation (1/1/2020-1/31/2022), early post-implementation (2/1/2022-1/31/2023), and late post-implementation (2/1/2023-1/31/2024) cohorts.

Conditional diffusion-generated super-resolution for myocardial perfusion MRI.

Introduction: Myocardial perfusion MRI is important for diagnosing coronary artery disease, but current clinical methods face challenges in balancing spatial resolution, temporal resolution, and slice coverage. Achieving broader slice coverage and higher temporal resolution is essential for accurately detecting abnormalities across different slice locations but remains difficult due to constraints in acquisition speed and heart rate variability. While techniques like parallel imaging and compressed sensing have significantly advanced perfusion imaging, they still suffer from noise amplification, residual artifacts, and potential temporal blurring due to the rapid transit of dynamic contrast vs.