Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions.

To understand shared and ancestry-specific genetic control of brain protein expression and its ramifications for disease, we mapped protein quantitative trait loci (pQTLs) in 1,362 brain proteomes from African American, Hispanic/Latin American and non-Hispanic white donors. Among the pQTLs that multiancestry fine-mapping MESuSiE confidently assigned as putative causal pQTLs in a specific population, most were shared across the three studied populations and are referred to as multiancestry causal pQTLs. These multiancestry causal pQTLs were enriched for exonic and promoter regions.

Enhancing Primary Care Capacity for Cardiovascular Disease Management Through the ECHO+ Model: A Multistate Rural Collaboration Among West Virginia, Arkansas, and Oklahoma.

Background: Cardiovascular diseases (CVD) are the leading cause of mortality in Arkansas, West Virginia, and Oklahoma, underscoring the need for approaches to build primary care capacity to address CVD in these states.

Methods: The "ECHO+" model integrates a CVD-focused tele-education course with quality improvement (QI) training and coaching to empower rural primary care providers (PCPs) in diagnosing and managing CVD effectively.

Results: 41 clinicians participated in the program.

Enzyme cascade-induced optical sensing of hyaluronidase using an ultraviolet-modified liquid crystal interface.

H yaluronidase (HAase) is a clinically significant enzyme involved in tumor progression, extracellular matrix remodeling, and inflammation. Hence, HAase is an important biomarker for disease diagnostics. Here, a label-free, pH-responsive biosensor using ultraviolet (UV)-treated liquid crystals (LCs) for HAase detection is presented.

Molecular impact of antisense oligonucleotide therapy in C9orf72-associated ALS.

C9orf72-associated amyotrophic lateral sclerosis (c9ALS) is caused by an intronic GC repeat expansion that leads to toxic RNA transcripts and dipeptide repeat proteins (DPRs). A clinical trial using the antisense oligonucleotide (ASO) BIIB078 to target these transcripts was discontinued after failing to provide clinical benefit. Here, we determine the extent of target engagement in the central nervous system (CNS) and elucidate pharmacodynamic cerebrospinal fluid (CSF) biomarkers following treatment.

Scoping review of nurse triage in primary care.

Aim: Triage in the primary care setting is critical for ensuring timely access to and continuity of care for patients. This scoping review examines how nurse triage is implemented, including the types of nurses involved, settings, triage algorithms, classification systems, and outcomes.

Methods: A search of five electronic databases, including PubMed, CINAHL, EMBASE, Web of Science, and Cochrane Central, was conducted in July 2025.