Unravelling the antifungal property of a type I crustin from Scylla olivacea: Membrane disruption and ROS generation as modes of action.

Crustins, among the earliest families of gene-encoded antimicrobial peptides (AMPs) identified in crustaceans, are disulfide-rich peptides (6-22 kDa) characterized by a conserved Whey Acidic Protein (WAP) domain at the C-terminal end. This domain features a disulfide core formed by eight highly conserved cysteines. Functionally, crustins exhibit diverse biological roles.

Harnessing a deep-sea EAL-domain enzyme for quorum quenching and biofilm control in food pipelines.

This study explores the potential of quorum-quenching (QQ) enzymes from deep-sea bacteria to disrupt bacterial communication and biofilm formation. Among 21 psychrophilic marine isolates, Vibrio sp. strain SAT06 showed broad-spectrum QQ activity by degrading both short (C-HSL) and long-chain (3-O-C-HSL) acyl homoserine lactones.

Unveiling the Modes of Action of a Recombinant Antimicrobial Peptide, Hepcidin (rGf-Hep), from Gerres filamentosus Against Pathogenic Vibrios: Membrane Disintegration and Reactive Oxygen Species Generation Leading to Cell Death.

Antimicrobial peptides (AMPs) are essential components of the innate immune response, which play a significant role in combating pathogenic infections. Hepcidin, a peptide hormone predominantly synthesized in the liver, has been identified to exhibit dual functions in iron metabolism and antimicrobial activity across various organisms. In this study, we describe the molecular characteristics, anti-vibrio activity, and mechanisms of action of a novel hepcidin isoform from the commercially important estuarine fish, Whipfin silver-biddy (Gerres filamentosus).

Insights into the antifungal properties and modes of action of a recombinant hepcidin, rAd-Hep from the shrimp scad, Alepes djedaba (Forsskål, 1775).

Antimicrobial peptides are short, mostly cationic and amphipathic molecules crucial for host defence. Among these, hepcidins are a family of cysteine rich peptides, with HAMP1 hepcidins playing a dual role in iron metabolism and antimicrobial defense. Recently, recombinantly produced Alepes djedaba hepcidin, rAd-Hep was characterized and its antibacterial potential against various pathogens have been discerned.

Bisphenol A-induced ovarian damage countered by luteolin: Experiments in in vitro CHO cells and in vivo PCOS phenotype zebrafish.

Bisphenol-A (BPA) is a widely used chemical that can harm the human body, including the reproductive system. BPA accumulates in the body and is found in 95 % of individuals due to everyday exposure through food, water, and skin absorption. BPA can impair female fertility by interfering with ovarian folliculogenesis, inhibiting follicular growth, and inducing atresia, leading to polycystic ovary syndrome (PCOS).