Review of engineered magnetic chitosan nanoparticles for drug delivery: Advances, challenges, and future prospects.

Magnetic chitosan nanoparticles represent a promising platform in targeted drug delivery by merging the biocompatibility and mucoadhesiveness of chitosan with the superparamagnetic iron-oxide cores magnetite (Fe₃O₄) or maghemite (γ-Fe₂O₃). This synergy enables enhanced therapeutic precision through external magnetic guidance, controlled release, and stimuli-responsive behavior. MCNPs are particularly valuable in oncology, allowing site-specific drug delivery, magnetic hyperthermia, and real-time imaging via MRI.

Broad-spectrum therapeutic potential of 4-phenylbutyrate in neurological and systemic diseases of viral and non-viral origin.

4-Phenylbutyrate (4-PBA), initially recognized for treating urea cycle disorders, has emerged as a potent therapeutic agent with broad-spectrum potential. As a chemical chaperone, 4-PBA modulates protein folding and reduces endoplasmic reticulum stress. 4-PBA has demonstrated efficacy in treating ocular herpes simplex virus type 1 (HSV-1) infection and HSV-1-induced encephalitis, highlighting its potential as a novel anti-herpetic therapy.

Chitosan polyplexes for targeted gene delivery: From mechanisms to clinical applications.

As a diverse natural polymer called Chitosan, it created ground-breaking advancements in nucleic acid therapeutic delivery techniques for handling essential DNA and RNA delivery hurdles. The article investigates how nucleic acids form stable polyplexes with chitosan through electrostatic bonds, as well as explores their chemical and biological properties. The review explores how molecular weight, combined with the degree of deacetylation, combined with advanced functionalization strategies, help enhance delivery results.

Burning love: digital escharotomy in the management of an electrothermal wedding band burn from a lawnmower battery. A case report.

Reporting of electrothermal ring burns in the literature is infrequent and comprise of a minimal amount of burn consults with no existing standardized approach to treatment and management. They are, however, a potentially serious burn as they have a propensity to be circumferential given the circular nature of rings, increasing the risk of compartment syndrome which may result in irreversible neurovascular damage and potential digit amputation if not treated in a timely manner, despite the very small total body surface area of the burn. This case report has demonstrated the success of digital escharotomy in the management of electro thermal ring injuries.

Brush, byte, and bot: quality comparison of artificial intelligence-generated pediatric dental advice across ChatGPT, Gemini, and Copilot.

Introduction: Artificial intelligence (AI) tools such as ChatGPT, Google Gemini, and Microsoft Copilot are increasingly relied upon by parents for immediate guidance on pediatric dental concerns. This study evaluated and compared the response quality of these AI platforms in addressing real-world parental queries related to pediatric dentistry, including early tooth extraction, space maintenance, and the decision to consult a pediatric or a general dentist.

Methods: A structured 30-question survey was developed and submitted to each AI model, and their responses were anonymized and assessed by pediatric dental experts using a standardized rubric across five key domains: clinical accuracy, clarity, completeness, relevance, and absence of misleading information.