Exceptional Response to Immunotherapy-based Treatment in Compound -Mutated Oligometastatic Pulmonary Sarcomatoid Carcinoma: A Case Report.

Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive subtype of non-small cell lung cancer (NSCLC) with limited treatment options and poor prognosis. mutations generally respond to tyrosine kinase inhibitors (TKIs)-based targeted therapy but are typically associated with resistance to immunotherapy. We report a case of oligometastatic PSC harboring compound mutations (p.

Liquid biopsy- A pivotal test to help navigate clinical decisions at a precision center in India!

Liquid biopsy, specifically circulating tumor DNA (ctDNA) analysis, has emerged as a transformative tool in precision oncology, providing real-time, minimally invasive characterizations of the tumor and tumor dynamics. While tissue biopsy is a critical tool for baseline diagnosis of malignancy, it is often limited by sampling constraints and an inability to capture tumor heterogeneity. In this study, we explored the clinical utility of serial ctDNA testing in guiding therapeutic decisions across a cohort of 30 patients with diverse solid tumors.

Assessment of the Clinical Efficacy and Safety of Azithromycin in Patients With Moderate to Severe Upper Respiratory Tract Infections (URTIs): Insights From an Indian Real-World Study.

Introduction Upper respiratory tract infections (URTIs) are commonly encountered in primary care. Azithromycin has emerged as a preferred therapy for URTIs due to its once-daily dosing, low resistance risk, and favorable gastrointestinal tolerability. This study evaluated the real-world effectiveness and safety of azithromycin (500 mg/day) in moderate to severe acute URTIs.

Proposed tripartite classification of T1 renal cell carcinoma: Comparison with current binary system.

Objective: Outcomes of stage 1 renal cell carcinoma (RCC) are heterogeneous and vary widely. We sought to investigate whether tripartite reclassification of current binary T1 RCC would lead to more rational consolidation of similar outcomes that may improve predictive ability.

Methods: We performed a retrospective multicenter analysis of patients undergoing radical (RN) or partial nephrectomy (PN) for clinical T1N0M0 RCC.

Enhanced Physico-Chemical and Electrical Characteristics of Hydrothermally Synthesized NiTiO via Tungsten Doping for Gas Sensing Applications.

Herein, tungsten-doped nickel titanate (WNiTiO3) nanoparticles are synthesized using hydrothermal route and investigated physicochemical and gas sensing properties. The effect of W-dopant concentrations on the physicochemical and electrical characteristics of NiTiO3 is systematically investigated. X-ray diffraction analysis revealed a consistent decrease in crystallite size, accompanied by an increase in dislocation density and micro-strain with higher W doping levels.