Amygdala-liver signalling orchestrates glycaemic responses to stress.

Behavioural adaptations to environmental threats are crucial for survival and necessitate rapid deployment of energy reserves. The amygdala coordinates behavioural adaptations to threats, but little is known about its involvement in underpinning metabolic adaptations. Here we show that acute stress activates medial amygdala (MeA) neurons that innervate the ventromedial hypothalamus (MeA neurons), which precipitates hyperglycaemia and hypophagia.

Acute Febrile Illness Associated with an Emerging Dengue 4 GIIb Variant Causing Epidemic in León, Nicaragua 2022.

Historically, DENV-4 has been rarely associated with epidemics and has been less well-studied than DENV-1 to -3. Epidemic dengue struck several South and Central American countries in 2022, with Nicaragua reporting the highest incidence. In an acute febrile illness (AFI) cohort enrolled from June to September 2022, 58 (34%) of 172 patients had PCR-confirmed dengue, of which 46 (79%) were serotyped as DENV-4.

Total Intravenous Versus Inhalational Anesthesia in High-Grade Glioma Surgery: A Systematic Review and Meta-Analysis.

: High-grade gliomas (HGGs) are aggressive primary brain tumors with a poor prognosis despite multimodal treatment. The anesthetic technique used during surgery may influence tumor progression and survival, but its role in HGGs remains unclear. This meta-analysis evaluated the effect of total intravenous anesthesia (TIVA) versus inhalational anesthesia (INHA) on overall survival (OS) and progression-free survival (PFS) in HGG patients.

Nutrient excess remodels islet autonomic innervation via pancreatic schwann cells.

Nutrient excess results in short- and long-term adaptations in the structure and function of metabolic organs, such as pancreatic islets. Pancreatic innervation contributes to islet architecture and function in many species, including humans, but little is known about its adaptation to over-nutrition. Here, we use 3D imaging to show that short-term high fat diet rapidly remodels islet sympathetic innervation while long-term high fat diet results in islet-specific cholinergic neuropathy.

Solvent-free mechanochemical access to phase-pure Cs-Co-Cl halometalates with tuneable electronic properties for energy applications.

We report a solvent-free mechanochemical route for the selectively synthesis of three different caesium cobalt chlorides: CsCoCl, CsCoCl, and CsCoCl, by simply tuning the CsCl : CoCl precursor ratio. This is the first comprehensive comparative study of these phases synthesized in pure form, enabling a clear correlation between composition, crystal structure, and optoelectronic properties. Each phase exhibits a unique Co coordination geometry: octahedral in CsCoCl and tetrahedral in CsCoCl and CsCoCl, as revealed by XRD, SEM-EDS, Raman, and XPS, with several features reported here for the first time.