Clinical Status of Exosomes: A Review.

Nano-sized extracellular vesicles enclosed by a lipid bilayer and secreted by various cell types including mesenchymal stem cells, exosomes act as natural transporters, carrying bioactive molecules such as proteins, lipids, and nucleic acids that mediate intercellular communication. Exosomes influence a range of cellular processes, including immune modulation, tissue repair, and disease progression. Compared to whole-cell therapies, exosomes provide anti-inflammatory, immunosuppressive, and regenerative effects with reduced risks linked to cellular components, such as infusion toxicity, immunogenicity, and tumorigenic phenomena.

Text Message Reminders About Free Transportation for Outpatient Substance Use Disorder Treatment: A Pilot Randomized Encouragement Study.

Introduction: Substance use disorders (SUDs) are a major epidemic in the USA. Patients who lack transportation may have limited access to outpatient SUD treatment programs and are less likely to remain in care. Encouraging the use of free, reliable transportation during enrollment is an untested mechanism for greater retention.

Pyriform Aperture Enlargement Through a Rhinoplasty Approach.

Background: The pyriform aperture can limit airflow in some patients. In this study, the authors describe a new surgical technique to access and modify the pyriform aperture.

Objectives: Describe the technique to measure the width of the pyriform aperture and surgically enlarge the pyriform aperture using ultrasonic instrumentation.

Real-world access to buprenorphine treatment in Philadelphia: A secret shopper study.

Purpose: To assess real-world access to buprenorphine treatment in Philadelphia and measure adoption of policies and practices that facilitate buprenorphine access.

Methods: We used an audit ("secret shopper") design to survey all programs providing longitudinal, outpatient buprenorphine in Philadelphia from 9/2022-1/2023 (n = 130). After validating eligibility, a research coordinator posing as a case manager called eligible programs to inquire about appointment availability and treatment policies.