CARDIAC MYOSIN BINDING PROTEIN-C ACTS AS A TUNABLE LOAD SENSOR TO REGULATE AFTERLOAD DEPENDENCE OF VENTRICULAR FUNCTION.

The sarcomeric protein cardiac myosin binding protein-C (cMyBP-C) binds myosin on thick filaments and regulates cardiac myocyte contraction. Our lab has reported that permeabilized cardiac myocytes lacking cMyBP-C generate greater power and show disproportionately fast sarcomere shortening velocities at high loads. Also, high resolution X-ray diffraction of cardiac trabeculae found that myosin cross-bridges in the cMyBP-C zone are the most active during loaded contractions.

Rural and Appalachian cancer survivors' responses to tobacco use screening and tobacco treatment offer.

Introduction: Smoking after a cancer diagnosis is associated with poor outcomes whereas smoking cessation improves survival and other outcomes. Although professional societies and practice guidelines call for equitable tobacco treatment delivery in healthcare, disparities in tobacco-related disease burden persist.

Methods: In the context of an outpatient US cancer center's population-based tobacco treatment program, this study examines associations between cancer survivors' rural and Appalachian residence status and: 1) current tobacco use status, 2) decision to decline tobacco treatment, and 3) reason for declining assistance.

Assisted Infant Toilet Training and Bladder and Bowel Health: A Global Integrative Review.

Background: Toilet training practices vary across cultures and time. Assisted Infant Toilet Training (AITT) is commonly used in low- and middle-income countries.

Objectives: To synthesise the literature on AITT, including timing of initiation and completion, infant elimination signalling, and associations with bladder and bowel dysfunction.

Improving cosmological reach of a gravitational wave observatory using Deep Loop Shaping.

Improved low-frequency sensitivity of gravitational wave observatories would unlock study of intermediate-mass black hole mergers and binary black hole eccentricity and provide early warnings for multimessenger observations of binary neutron star mergers. Today's mirror stabilization control injects harmful noise, constituting a major obstacle to sensitivity improvements. We eliminated this noise through Deep Loop Shaping, a reinforcement learning method using frequency domain rewards.

Growth Performance, Blood Chemistry, and Intestinal Bacterial Community of Florida Pompano () Fed Different Levels of Corn Fermented Protein and Yeast Diets.

Developing species-specific diets for Florida pompano () requires understanding both nutritional needs and ingredient responses in practical formulations. Previous research has successfully reduced animal protein inclusion to ~15% by using solvent-extracted soybean meal (SBM) as the primary protein source. Further cost savings may be achieved by incorporating other low-cost alternatives, such as corn fermented protein (CFP), a new sustainable ingredient produced using Fluid Quip Technologies.