MksEF Accessory Proteins Inhibit MksB ATPase Activity and Modulate DNA Substrate Binding.

Chromosome organization and segregation are fundamental processes across all domains of life. In bacteria, the mechanisms governing nucleoid organization remain poorly understood. This study investigates the function of an alternative structural maintenance of chromosomes (SMC) complex, MksBEF, in .

Outpatient Endocrine Protocol and Testing Coincides with Reduced Length of Postpituitary Surgery Admission.

Objective: The study objective was to compare the length of stay (LOS) and the proportion of one-night admissions before and after the implementation of an endocrine monitoring protocol following endoscopic transsphenoidal surgery (ETSS) for pituitary adenoma.

Methods: Patients who underwent transsphenoidal pituitary adenoma resection between July 1, 2018, and September 9, 2022, were identified, and divided into two cohorts before and after the implementation of the monitoring protocol. The overall LOS and number of nights of admission were recorded.

Biphasic Ni-MXene Quantum-Confined Nanostructures: A Versatile Janus Platform for Advanced Energy Storage and Catalytic Oxidations.

The demand for sustainable energy storage and ecofriendly catalysts has intensified the search for advanced multifunctional materials. Herein, this work presents the synthesis and characterization of Janus Ni-MXene quantum dot (Ni-MJQD), a novel material architecture that exhibits high performance in supercapacitor and catalytic applications. A Ni-MJQD cathode delivers an impressive gravimetric specific capacity of 168.

Targeted Drug Delivery for Breast Cancer using Functionalized Liposomes: Preparation Methods, Challenges, and Clinical Translation.

Breast cancer continues to be a major cause to cancer-related deaths globally, highlighting the urgent need for more targeted and efficient treatment approaches. This review focuses on targeted drug delivery systems using functionalized liposomes, which have emerged as promising nanocarriers due to their ability to improve drug solubility, stability, and site-specific delivery. They alter a drug's pharmacokinetics and biodistribution to improve pharmacological efficacy while minimizing systemic toxicity.

Unique Polyester-Based Biodegradable Multiarm Nano-Carrier for Cancer Cell Specific Mitochondrial Delivery of Chemotherapeutics.

Biodegradable polymeric nanocarriers hold significant potential for various biomedical applications, enabling the targeted and controlled delivery of drugs and bioactive molecules. In this context, pendant-functionalized polycaprolactone has garnered tremendous attention over the past few decades. Herein, we developed a mitochondria-targeted polycaprolactone-based polyprodrug, , for the site-specific delivery of camptothecin (CPT).