Time-varying impact of established prognostic factors in resected pancreatic ductal adenocarcinoma.

Background: Prognostic factors in resected pancreatic ductal adenocarcinoma (PDAC) have been determined under the assumption that hazard ratios (HRs) remain static. However, PDAC is a dynamic disease with evolving conditional survival. The aim of this study was to determine if the impact of prognostic factors in PDAC is time-varying.

Effects of fully immersive virtual reality on nurses' knowledge, decision-making, self-efficacy and engagement.

Aim: This study examined the impact of fully immersive virtual reality (FIVR) on knowledge, decision-making, self-efficacy and engagement compared with traditional onboarding methods.

Background: Newly graduated nurses often face challenges in managing medical crises, including emergencies such as diabetes-related ketoacidosis (DKA). Addressing these challenges during onboarding is essential to prepare them for providing effective and timely care in acute settings.

The impact of perioperative chemotherapy in patients with pancreatic adenosquamous carcinoma.

Background: Pancreatic adenosquamous carcinoma has historically poor overall survival, and the impact of perioperative chemotherapy remains unclear. We aimed to evaluate the impact of various chemotherapy regimens in patients with resected adenosquamous carcinoma.

Methods: Patients with resected adenosquamous carcinoma were identified from 3 high-volume programs between 2001 and 2022.

Is cultural context the crucial touch? Neurophysiological and self-reported responses to affective touch in women in South Africa and the United Kingdom.

Affective touch, involving touch-sensitive C-tactile (CT) afferent nerve fibres, is integral to human development and wellbeing. Despite presumed cultural differences, affective touch research typically includes 'Western', minority-world contexts, with findings extrapolated cross-culturally. We report the first cross-cultural study to experimentally investigate subjective and neurophysiological correlates of affective touch in women in South Africa (SA) and the United Kingdom (UK) using (1) touch ratings, and (2) cortical oscillations for slow CT-optimal (vs.

Incidence and Outcomes of Intraductal Oncocytic Papillary Neoplasm-Derived Pancreatic Cancer Compared with Tubular and Colloid Intraductal Papillary Mucinous Neoplasm-Derived Pancreatic Cancer: An International Multicenter Retrospective Study.

Background: Intraductal papillary mucinous neoplasm (IPMN)-derived pancreatic cancer was previously categorized into tubular, colloid, and oncocytic subtypes. Intraductal oncocytic papillary neoplasms (IOPN) has long been associated with superior prognosis/indolent behavior, however, there is discordant emerging evidence. This study aimed to investigate this conflicting literature.