Insulin- and glucagon-producing cells in the liver and biliary-pancreatic axis of rats with experimentally induced metabolic syndrome.

Context: The generation of insulin-producing cells (IPCs) as cell replacement therapy for diabetes treatment is challenging.

Objective: We have evaluated the presence of insulin-positive (insulin) and glucagon-positive (glucagon) cells in hepatocytes, peribiliary glands (PBGs), and liver sinusoidal endothelial cells (LSECs).

Materials And Methods: Wistar rats are subjected to a diet including administration of 15% fructose solution for 3 months.

Development of pancreatic islet cells in the extrahepatic bile ducts of rats with experimentally-induced metabolic syndrome.

Context: There is data about the existence of some endocrine cells in the epithelial layer of the bile duct in humans and rats.

Objective: We evaluated Ghrelin-, Insulin-, Glucagon- and Somatostatin-positive cells in peribiliary glands, mast cells, and nerve fibres.

Materials And Methods: Wistar rats were used for dietary manipulation with a 15% fructose solution for 12 weeks.