Unveiling Vaginal Fibrosis: A Novel Murine Model Using Bleomycin and Epithelial Disruption.

Vaginal fibrosis induced by cancer therapy continues to take a physical and psychoemotional burden. To advance the efforts to generate a reproducible and cost-effective animal model, we tested the effect of repeated bleomycin instillations with mucosal layer disruption on induction of vaginal fibrosis. Tissue samples collected at various time points were analyzed for fibrosis-related gene expression changes and collagen content.

Postural sway dynamics in adults across the autism spectrum: a multifactor approach.

Background: Motor challenges are highly prevalent within autism, and increased postural sway has been consistently demonstrated in autistic youth. However, the extent to which sway anomalies extend into adulthood remains understudied. This study aimed to investigate whether increased postural sway is altered in autistic adults compared to neurotypical controls using established sway metrics including sway area and path, as well as rambling-trembling decomposition—an approach that differentiates the postural sway signal into central and peripheral nervous system components.

Morphodynamics and management challenges for beaches in modified estuaries and bays.

There is a relative lack of research, targeted models and tools to manage beaches in estuaries and bays (BEBs). Many estuaries and bays have been highly modified and urbanised, for example port developments and coastal revetments. This paper outlines the complications and opportunities for conserving and managing BEBs in modified estuaries.

Characterization of the Effects of Sex, Speed, and Incline on Metabolic Rate during Partial Gravity Ambulation.

With the Artemis missions returning humans to the Moon, characterizing ambulation and metabolic rate in partial gravity environments is critical for spacesuit design, mission planning, and architecture. To date, no study has assessed the combined effects of sex, speed, and incline on metabolic rate across a broad range of partial gravity levels. In this study, twelve subjects ambulated on a treadmill under sixteen conditions combining speeds (3 mph and 4 mph), gravity levels (0.

Readability of Pediatric Otolaryngology Information: Comparing AI-Generated Content With Google Search Results.

Objective: This study evaluates and compares the readability of pediatric otolaryngology patient education materials generated by ChatGPT4o and those retrieved from Google searches. The goal is to determine whether artificial intelligence (AI)-generated content improves accessibility compared to institutionally affiliated online resources.

Study Design: Cross-sectional readability analysis.