Diagnostic value of the wnt target and cancer-associated blood biomarker hPG80: ONCOPRO case-control prospective study.

Background: hPG (circulating progastrin), initially recognized for its oncogenic properties due to its direct link to the Wnt signaling pathway, is secreted by cancer cells and detectable in the blood of cancer patients. The ONCOPRO centralized case-control study (NCT03787056) was designed to prospectively evaluate the diagnostic utility of hPG in patients with 16 different types of cancer.

Methods: hPG levels were measured in 421 patients with 16 newly diagnosed cancers (median age 65.

First rangewide density estimate of the endemic and isolated Luangwa giraffe in Zambia.

The Luangwa giraffe (Giraffa tippelskirchi thornicrofti), a subspecies of the Masai giraffe endemic to the Luangwa Valley of northeastern Zambia, inhabits an increasingly human-modified landscape. Accurate and current population estimates are critical to evaluating their status and identifying effective conservation strategies. However, sparse monitoring since the early 1900s has limited inferences about population size, structure, and range.

Correction: Large-scale releases and establishment of wMel Wolbachia in Aedes aegypti mosquitoes throughout the Cities of Bello, Medellín and Itagüí, Colombia.

[This corrects the article DOI: 10.1371/journal.pntd.

Interdisciplinary Strategies to Reduce Surgical Infectious Risk in the Operating Theater: Protocol for Scoping Review.

Background: Surgical site infections (SSIs) represent one of the most prevalent and significant complications associated with surgical procedures, often leading to prolonged hospitalization and delayed patient recovery. While recent international consensus guidelines have proposed evidence-based strategies to mitigate SSIs, they fall short in addressing the efficient and interdisciplinary implementation of these measures within the operating theater. Consequently, further research is required to identify and evaluate optimal interdisciplinary organizational approaches for the prevention of SSIs.