Enzyme-mediated nanoreactors with cascade metabolic modulation for enhanced chemo-chemodynamic combination therapy.

Harnessing the significant buildup of lactic acid (LA) within the tumor microenvironment (TME) for metabolic manipulation presents a promising avenue for cancer treatment. Nevertheless, single-agent therapies often fail to address the complex and varying needs of TME heterogeneity, posing a substantial scientific hurdle in oncology. In this context, we employ asymmetric mesoporous silica nanoparticles (AMS NPs) as delivery vehicles, simultaneously loading them with zinc‑cobalt‑manganese ferrite nanoparticles (ZCMF NPs), lactate oxidase (LOX), and doxorubicin (DOX).

Effectiveness of emotional freedom techniques therapy in alleviating anticipatory grief for cancer patients.

Background: Cancer patients frequently experience anticipatory grief (AG), anxiety, and sleep disturbances. This randomized controlled trial evaluates the efficacy of the emotional freedom technique (EFT) therapy in alleviating these symptoms.

Methods: A total of 58 cancer patients were randomly assigned to an intervention group (n = 30) receiving 4-week EFT therapy (acupoint tapping + scripted prompts, 5 minutes per prompt) plus routine care, or a control group (n = 28) receiving routine care alone.

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53 Mutation and is a Potential Therapeutic Target.

TP53 mutations are highly associated with hepatocellular carcinoma (HCC), a common and deadly cancer. However, few primary drivers in the progression of HCC with mutant TP53 have been identified. To uncover tumor suppressors in human HCC, a genome-wide CRISPR/Cas9-based screening of primary human hepatocytes with MYC and TP53 overexpression (MT-PHHs) is performed in xenografts.

Causing Perioral Cutaneous Infection: A Rare Case Easily Misdiagnosed.

Cutaneous cryptococcosis is rarely caused by , especially in immunocompetent individuals. We report a unique case of perioral cutaneous infection in a 37-year-old male with scattered erythematous, pruritic, and scaly lesions lasting over a month. Initial clinical presentation mimicked common dermatological conditions, leading to potential misdiagnosis.

Birth weight, cardiovascular health, and the risk of cardiovascular disease: A longitudinal perspective from the UK biobank cohort.

Background: The associations between birth weight (BW), cardiovascular health (CVH) as assessed by Life's Essential 8 (LE8) and cardiovascular diseases (CVDs) remain unclear. We aimed to assess the independent and joint associations of BW and CVH with risks of CVDs.

Methods: This study included 143,910 UK Biobank participants without CVD at baseline (2006-2010).