Effectiveness and Costs of Molecular Screening and Treatment for Bacterial Vaginosis to Prevent Preterm Birth: The AuTop Randomized Clinical Trial.

Importance: Bacterial vaginosis (BV) is a well-known risk factor for preterm birth. Molecular diagnosis of BV is now available. Its impact in the screening and treatment of BV during pregnancy on preterm births has not been evaluated to date.

A case of congenital toxoplasmosis-associated miscarriage with maternal infection four months prior to conception.

Background: We report a case of fatal congenital toxoplasmosis with maternal infection dated four months before pregnancy in the absence of any specific immunosuppressive condition.

Case: Ms. D.

HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome.

Hypoxia stabilizes HIF-1alpha (Hypoxia Inducible Factor-1alpha), which then triggers the expression of several genes involved in many aspects of cancer progression, including metabolic adaptation, cell survival and angiogenesis. The aim of our study was to evaluate the impact of HIF-1alpha and CA IX (carbonic anhydrase IX) (one of its target genes) expression on prognosis and treatment outcome of patients with breast cancer. Because of the extreme O2-dependent instability of the protein, we first validated HIF-1alpha staining using xenograft tumours that were subjected to experimental conditions mimicking surgical clamping or sitting at room temperature under normoxic conditions after surgical excision but before fixation.

Comparison between monofilament and multifilament polypropylene tapes in urinary incontinence.

Objective: We compare the efficacy and late complications between a polypropylene monofilament tape (TVT) and a polypropylene multifilament tape (IVS) in the surgical implant of sub-urethral, tension free tape for the treatment of stress urinary incontinence (SUI).

Methods: It is a non-randomised, monocentric retrospective study. Two questionnaires were sent to the patients.

Spontaneous rupture and hemorrhage of hepatic focal nodular hyperplasia in lobus caudatus.

In general, focal nodular hyperplasia lesions of the liver have a benign natural course; the majority of cases remain asymptomatic and complications are rare. We report a case of spontaneous rupture and hemorrhage of focal nodular hyperplasia, which is extremely rare in the literature. A 35-year-old woman was admitted with severe upper abdominal pain and unstable hemodynamic status.

Multifilament polypropylene mesh for urinary incontinence: 10 cases of infections requiring removal of the sling.

One hundred and forty-nine women received a suburethral woven polypropylene mesh insertion for urodynamic stress incontinence. Eleven patients (7.5%) presented between 4 and 17 months after surgery (mean 10 months) with symptoms of retropubic infection.

Hematogenous rectal metastasis 20 years after removal of epithelial ovarian cancer.

Background: Rectal tumors are rarely metastatic. Moreover, hematogenous spread is rare in ovarian cancer whose dissemination frequently occurs through peritoneal or lymphatic ways.

Case: A 55-year-old female presented with a rectal metastasis that appeared 20 years after the treatment of a primary clear cell carcinoma of the ovary.

[Surgery of tubal lesions with favourable prognosis].

Presently, open microsurgery and laparoscopic microsurgery must be used for the treatment of tubal lesions with favourable prognosis (70% of proximal tubal lesions and 45% of distal tubal lesions) because, in these lesions, the results are better than these obtained by in vitro fertilization. Essential principles of microsurgery must be respected by the tubal surgery.