Publications by authors named "Cui-Qing Xie"
Background: NUAK1 is associated with metastasis and drug resistance in hepatocellular carcinoma (HCC). However, little is known about the immune functions of NUAK1 in HCC. Therefore, the aim of this study was to elucidate the novel role of NUAK1 in facilitating immune evasion in HCC and to investigate the mechanisms underpinning this process.
View Article and Find Full Text PDFAndrographolide sensitizes glioma to temozolomide by inhibiting DKK1 expression.
Zhan-Sheng Zhang
,
Zi-Xuan Gao
,
Jin-Jin He
,
Can Ma
,
Hang-Tian Tao
,
Cui-Qing Xie
,
Song-Qiang Xie
Br J Cancer
November 2024
Background: Temozolomide (TMZ) is the first-line chemotherapeutic drug for gliomas treatment. However, the clinical efficacy of TMZ in glioma patients was very limited. Therefore, it is urgently needed to discover a novel approach to increase the sensitivity of glioma cells to TMZ.
View Article and Find Full Text PDFArticle Synopsis
- - Chemotherapy combined with immunotherapy shows promise for treating breast cancer, but current treatments with paclitaxel and PD-1/PD-L1 inhibitors have limited effectiveness and side effects, like peripheral neuropathy.
- - Research identified that the protein Dickkopf-1 (DKK1) is increased after paclitaxel treatment, negatively affecting T cell activity and limiting the drug's antitumor effects.
- - Using an anti-DKK1 antibody alongside paclitaxel improved cancer treatment outcomes and reduced neuropathy symptoms in mouse models, suggesting a new approach for safer breast cancer therapies.