NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers.

NSD2 catalyses the epigenetic modification H3K36me2 (refs. ) and is a candidate convergent downstream effector of oncogenic signalling in diverse malignancies. However, it remains unclear whether the enzymatic activity of NSD2 is therapeutically targetable.

Perspectives and experiences of induction of labour: An Australian cross-sectional study.

Problem: Despite being the most common obstetric intervention, little is known about women's experiences of induction of labour (IOL).

Background: Rates of IOL have risen by 43 % in the past decade in Australia. There is limited evidence regarding women's experiences of IOL.

Synthesis using prospective meta-analysis to reduce youths' e-cigarette use (SPARKE): a protocol for an individual participant data prospective meta-analysis (IPD PMA) examining interventions for the prevention of youth e-cigarette use.

Introduction: Youth electronic cigarette (e-cigarette) use is a global health challenge, with multiple jurisdictions wrestling with appropriate responses, in the face of limited evidence available on effective interventions. Identifying and synthesising evidence on the effects of interventions to prevent youth e-cigarette use is required to inform prevention-focussed health policy and practice.

Methods And Analysis: We plan to undertake an individual participant data (IPD) prospective meta-analysis (PMA).

Adapting the Nutrition and Physical Activity Self-Assessment: A Cross-Country Case Study of Improving Early Childhood Health Environments in the United States, Australia, and the United Kingdom.

Child overweight and obesity is a critical global health issue with substantial individual and societal impacts necessitating early intervention to establish healthy habits. Health promoting early childhood education (ECE) settings are important as most young children attend ECEs in high- and middle-income countries. Nutrition and Physical Activity Self-Assessment for Child Care (NAPSACC) is an evidence-based approach to support improvements to ECE environment for improving child health.

Are Text-Message Based Programmes Targeting Adolescents and Their Parents an Acceptable Approach to Preventing Adolescent e-Cigarette Use?

Issue Addressed: Increasing rates of e-cigarette use amongst adolescents has been identified as a public health concern, due to negative health effects and the association with an increased risk of tobacco use. Effective strategies to prevent e-cigarette uptake are required. Text-message programmes represent a potentially effective and cost-effective approach, that is also minimally invasive, but acceptability amongst adolescents and their parents is unclear.

A morphometric analysis of the cranial base in trigonocephaly.

Trigonocephaly occurs when the metopic suture fuses prematurely. Few studies have documented the morphometry of the entire anterior cranium in trigonocephaly and not on the morphometric changes to the cranial fossae alone. Thus, this study aimed to determine and compare the dimensions of the anterior cranial fossa (ACF) in trigonocephaly and control groups.

Improving the adoption of a school-based nutrition program: findings from a collaborative network of randomised trials.

Background: Public health nutrition interventions, including school-based programs, are a recommended approach to improve child dietary behaviours. However, the adoption of effective school-based nutrition programs face numerous challenges, including the limited evidence on effective strategies to maximise implementation and adoption of such programs. This study aimed to address this evidence gap by employing a novel collaborative network trial design to evaluate a series of implementation strategies employed by three NSW Local Health Districts, to improve school adoption of an effective school-based nutrition program ('SWAP IT').

Strategies for enhancing the implementation of school-based policies or practices targeting diet, physical activity, obesity, tobacco or alcohol use.

Background: A range of school-based interventions are effective in improving student diet and physical activity (e.g. school food policy interventions and classroom physical activity interventions), and reducing obesity, tobacco use and/or alcohol use (e.

Learning health systems to implement chronic disease prevention programs: A novel framework and perspectives from an Australian health service.

Background: Chronic diseases are a considerable burden to health systems, communities, and patients. Much of this burden, however, could be prevented if interventions effective in reducing chronic disease risks were routinely implemented.

Aims: The aim of this paper is to discuss the role of public health agencies in preventing chronic disease through the application of learning health system (LHS) approaches to improve the implementation of evidence-based interventions.

Factorial randomised controlled trial to examine the potential effect of a text message-based intervention on reducing adolescent susceptibility to e-cigarette use: a study protocol.

Introduction: Adolescent e-cigarette use, globally and within Australia, has increased in recent years. In response, public health agencies have called for the development of education and communication programmes targeting adolescents. Despite such recommendations, few rigorous evaluations of such interventions currently exist.

Interventions in the workplace to reduce risk factors for noncommunicable diseases: an umbrella review of systematic reviews of effectiveness.

Background: Workplaces are an important setting to deliver programs to reduce risk factors for noncommunicable diseases (NCDs). To help decision makers understand the most current and relevant evidence regarding effectiveness of workplace programs, we conducted an umbrella review to present a comprehensive synthesis of the large volume of literature.

Methods: Systematic reviews of workplace interventions targeting primary risk factors for NCDs-unhealthy diet, insufficient physical activity, overweight/obesity, tobacco use, and/or excessive alcohol use-published since 2010 were sourced.

A collaborative network trial to evaluate the effectiveness of implementation strategies to maximize adoption of a school-based healthy lunchbox program: a study protocol.

Introduction: An important impediment to the large-scale adoption of evidence-based school nutrition interventions is the lack of evidence on effective strategies to implement them. This paper describes the protocol for a "Collaborative Network Trial" to support the simultaneous testing of different strategies undertaken by New South Wales Local Health Districts to facilitate the adoption of an effective school-based healthy lunchbox program ('SWAP IT'). The primary objective of this study is to assess the effectiveness of different implementation strategies to increase school adoption of the SWAP across New South Wales Local Health Districts.

Factors associated with child and adolescent electronic nicotine and non-nicotine delivery systems use: A scoping review.

Objectives: To identify, characterise and broadly synthesise factors associated with child and adolescent electronic nicotine delivery systems (ENDS) and/or electronic non-nicotine delivery systems (ENNDS) ever-use and/or current use.

Methods: Four electronic databases were searched from inception to 3rd June 2022. Non-experimental studies that provided quantitative factors associated with adolescent and/or child ENDS or ENNDS ever-use and/or current use were included.

The Effectiveness of Strategies to Improve User Engagement With Digital Health Interventions Targeting Nutrition, Physical Activity, and Overweight and Obesity: Systematic Review and Meta-Analysis.

Background: Digital health interventions (DHIs) are effective in improving poor nutrition, physical inactivity, overweight and obesity. There is evidence suggesting that the impact of DHIs may be enhanced by improving user engagement. However, little is known about the overall effectiveness of strategies on engagement with DHIs.

Disseminating health research to public health policy-makers and practitioners: a survey of source, message content and delivery modality preferences.

Background: Understanding the views of policy-makers and practitioners regarding how best to communicate research evidence is important to support research use in their decision-making.

Aim: To quantify and describe public health policy-makers and practitioners' views regarding the source, content and form of messages describing public health research findings to inform their decision-making. We also sought to examine differences in preferences between public health policy-makers and practitioners.

Interventions to prevent or cease electronic cigarette use in children and adolescents.

Background: The prevalence of e-cigarette use has increased globally amongst children and adolescents in recent years. In response to the increasing prevalence and emerging evidence about the potential harms of e-cigarettes in children and adolescents, leading public health organisations have called for approaches to address increasing e-cigarette use. Whilst evaluations of approaches to reduce uptake and use regularly appear in the literature, the collective long-term benefit of these is currently unclear.

Development and piloting of a Community of Practice to support learning and improvement in health promotion practice within NSW local health district.

Objectives: Health Promotion Units within New South Wales (NSW) local health districts (LHDs) frequently collaborate and test innovations to address priority health issues or approaches to support the implementation of a health promotion program in a way that is consistent with the needs, resources, and contexts of their regions. Compatible with learning health system approaches, mechanisms to facilitate the exchange of evidence and expertise across districts could improve the collective impact of health promotion services across the state. This study aimed to assess the use of a health promotion Community of Practice (CoP) model as a strategy to achieve this.

Healthy eating interventions delivered in early childhood education and care settings for improving the diet of children aged six months to six years.

Background: Dietary intake during early childhood can have implications on child health and developmental trajectories. Early childhood education and care (ECEC) services are recommended settings to deliver healthy eating interventions as they provide access to many children during this important period. Healthy eating interventions delivered in ECEC settings can include strategies targeting the curriculum (e.

Women's perspectives of nitrous oxide for labour and procedural analgesia: A prospective clinical audit and cross-sectional study. "It's the best thing".

Problem: There is limited data regarding dose and duration of nitrous oxide use by women in peripartum care. Experiences of using nitrous in Australian settings have not previously been explored BACKGROUND: More than 1:2 women use nitrous oxide analgesia during labour and birth, despite this, there are limited published data on nitrous oxide use for labour or procedural analgesia in Australia.

Aim: To explore the use of nitrous oxide during labour and birth or procedural care.

A survey of Australian midwives: Experts in nitrous oxide administration within the peripartum setting.

Problem: There is little documented evidence of midwives' perspectives regarding the use of nitrous oxide in the peripartum period.

Background: Nitrous oxide is an inhaled gas used widely in the peripartum period; usually offered and managed by midwives.

Aim: Explore midwives' knowledge, perceptions, and practices of facilitating women's use of nitrous oxide in the peripartum period.

Healthy eating interventions delivered in early childhood education and care settings for improving the diet of children aged six months to six years.

Background: Dietary intake during early childhood can have implications on child health and developmental trajectories. Early childhood education and care (ECEC) services are recommended settings to deliver healthy eating interventions as they provide access to many children during this important period. Healthy eating interventions delivered in ECEC settings can include strategies targeting the curriculum (e.

Using a scheduled caesarean birth plan: A cross-sectional exploration of women's perspectives.

Problem: There is minimal evidence regarding the role or impact of birth plans from the perspective of women experiencing scheduled caesarean birth.

Background: Quality maternity care requires respect for women's preferences. Evidence suggests birth plans enable communication of women's preferences and may enhance agency when vaginal birth is intended, however there is limited evidence of how this translates in the perioperative environment where caesarean birth is the intended outcome.

Strategies for enhancing the implementation of school-based policies or practices targeting diet, physical activity, obesity, tobacco or alcohol use.

Background: Several school-based interventions are effective in improving child diet and physical activity, and preventing excessive weight gain, and tobacco or harmful alcohol use. However, schools are frequently unsuccessful in implementing such evidence-based interventions.

Objectives: 1.