Prostate cancer as an occupational disease: the actual impact in a high-incidence area.

Introduction: In Guadeloupe, prostate cancer (PCa) shows very high incidence rates. This over-incidence is associated with the historical use of chlordecone in banana plantations. Since December 2021, PCa has been recognized as an occupational disease for agricultural workers exposed to this pesticide.

A 2.5-20 kSps in-pixel direct digitization ECoG front-end with sub-millisecond stimulation artifact recovery.

Neural stimulation is used routinely to diagnose and treat neurological disorders. However, the stimulation artifacts are problematic for closed-loop neuromodulation therapy, which dynamically adjusts the electrical stimulation parameters based on real-time feedback from recording neural activity, because they can cause saturation or prolonged recovery times in traditional recording front-ends. This paper presents a per-pixel 2-order ADC for direct digitization of neural signals, which addresses the stimulation artifact recovery time in voltage-controlled oscillator (VCO)-based quantizers with a fast-recovery, overrange-detecting phase quantizer.

Neoadjuvant immunochemotherapy in the treatment of nonmetastatic muscle-invasive bladder cancer: a systematic review.

Multiple trials are currently studying the additional effect of immunotherapy on neoadjuvant chemotherapy (NAC) in nonmetastatic muscle-invasive bladder cancer. We performed a systematic review of the literature that summarizes all ongoing trials, with their results when available. From an initial 269 trials identified, 17 were included.

A 174.7-dB FoM, 2-Order VCO-Based ExG-to-Digital Front-End Using a Multi-Phase Gated-Inverted-Ring Oscillator Quantizer.

This paper presents a second-order voltage-controlled oscillator (VCO)-based front-end for the direct digitization of biopotential signals. This work addresses the non-linearity of VCO-based ADC architectures with a mismatch resilient, multi-phase quantizer, a gated-inverted-ring oscillator (GIRO), achieving >110-dB SFDR. Leveraging the time-domain encoding of the first integrator, the ADC's power is dynamically scaled with the input amplitude enabling up to 35% power savings in the absence of motion artifacts or interference.

Biocatalytic synthesis of planar chiral macrocycles.

Macrocycles can restrict the rotation of substituents through steric repulsions, locking in conformations that provide or enhance the activities of pharmaceuticals, agrochemicals, aroma chemicals, and materials. In many cases, the arrangement of substituents in the macrocycle imparts an element of planar chirality. The difficulty in predicting when planar chirality will arise, as well as the limited number of synthetic methods to impart selectivity, have led to planar chirality being regarded as an irritant.