Publications by authors named "Corentin Levacher"
Diagnostic analysis of mRNA is essential because altered splicing is a frequent cause of genetic diseases. High-throughput splicing studies remain difficult to implement in routine diagnostics. This is why SEALigHTS (splice and expression analyses by ligation and high throughput sequencing), a cost-effective and easy-to-implement technique designed for simultaneous analysis of RNA from multiple patients on a panel of genes, was developed using probes designed at exon extremities.
View Article and Find Full Text PDFBackground: Li-Fraumeni syndrome (LFS) predisposes individuals to a wide range of cancers from childhood onwards, underscoring the crucial need for accurate interpretation of germline variants for optimal clinical management of patients and families. Several unclassified variants, particularly those potentially affecting splicing, require specialised testing. One such example is the NM_000546.
View Article and Find Full Text PDFArticle Synopsis
- Breast cancer detection and prognosis are difficult due to the need for effective biomarkers, and the role of circRNAs in this process is being explored.
- Researchers created a new method called SEALigHTS to study the interplay between circular RNAs and mRNAs in breast tissue samples.
- Their findings indicate that the balance between circRNAs and mRNAs is disrupted in tumor tissues, supporting the idea that this imbalance contributes to the development of breast cancer.