Recent exploration of inorganic sonosensitizers for sonodynamic therapy of tumors.

With the rapid development of nanomedicine and nanobiotechnology, various therapeutic methods have been applied with good efficacy and biological safety. As a non-invasive treatment method, sonodynamic therapy (SDT) can effectively treat deep tumors with less damage to the surrounding tissue and high adaptability. The ultrasound sensitizer is an indispensable and important part of the SDT process, and its structure and properties directly determine the therapeutic effect of SDT.

Virtual Screening-Based Study of Novel Anti-Cancer Drugs Targeting G-Quadruplex.

In order to develop new anti-cancer drugs more efficiently and reduce side effects based on active drug targets, the virtual drug screening was carried out through the target of G-quadruplexes and 23 hit compounds were, thus, screened out as potential anticancer drugs. Six classical G-quadruplex complexes were introduced as query molecules, and the three-dimensional similarity of molecules was calculated by shape feature similarity (SHAFTS) method so as to reduce the range of potential compounds. Afterwards, the molecular docking technology was utilized to perform the final screening followed by the exploration of the binding between each compound and four different structures of G-quadruplex.

Potent saccharinate-containing palladium(II) complexes for sensitization to cancer therapy.

Palladium(II) (Pd) complexes are among the most promising anticancer compounds. Both 2`-benzoylpyridine thiosemicarbazone (BpT) and saccharinate (Sac) are efficient metal chelators with potent anticancer activity. To explore a more effective new anticancer drug, we synthesized a series of Sac and BpT-containing Pd complexes coordinated with thiosemicarbazone (TSC)-derived ligands, and characterized them through nuclear magnetic resonance (NMR), Fourier transformed infrared spectroscopy (FT-IR), elemental analysis, ultraviolet-visible spectroscopy (UV-Vis) and thermogravimetric analysis (TGA).