Exercise-induced symptoms in young childhood cancer survivors.

Purpose: Exercise-induced symptoms (EIS) are common in children and understudied in childhood cancer survivors (CCS). We assessed the prevalence of EIS in CCS and identified associated risk factors.

Methods: We included CCS aged 6-21 years who were diagnosed with cancer ≥ 1 year before study entry, were treated with systemic anticancer treatment, chest surgery, radiotherapy, or hematopoietic stem cell transplantation, completed cancer treatment, and received pediatric oncology follow-up care.

InfoKids+: A Validation Study of a Pediatric Acuity Risk Stratification Algorithm.

Objective: To prospectively validate InfoKids+, a pediatric acuity electronic risk stratification algorithm (eRSA), against a nurse-based triage standard (nbTS).

Participants And Methods: We conducted a prospective validation study in a Swiss university hospital pediatric emergency department to assess the performance of a pediatric acuity eRSA, InfoKids+, on the basis of a well-established parental guidance application, InfoKids. Participants completed the eRSA once seated in a consultation booth.

Natural variability of lung function in primary ciliary dyskinesia: longitudinal analysis from the PROVALF-PCD cohort.

Background: The extent to which changes in lung function are due to natural variability in patients with primary ciliary dyskinesia (PCD) is unknown. We aimed to assess intra-individual variability in forced expiratory volume in 1 s (FEV) derived from spirometry to define the extent to which the observed changes were due to test variability in clinically stable PCD patients.

Methods: PROVALF-PCD (Prospective Observational Multicentre Study on Variability of Lung Function in Stable PCD Patients) was a large international prospective cohort conducted in 2017-2019.

'Nobody Has Ever Spoken to Me About PCD and Fertility Issues': Fertility Experiences of People With Primary Ciliary Dyskinesia and Their Family Caregivers.

Background: Primary ciliary dyskinesia (PCD) affects fertility in both females and males. To understand the impact and concerns among people with PCD and parents of affected children (family caregivers), we explored how they report their experiences with fertility.

Methods: We used qualitative data from a questionnaire on fertility from Living with PCD, an international participatory study.

Reporting of paediatric exercise-induced respiratory symptoms by physicians and parents: an observational prospective study.

Study Aims: Routinely collected health data are increasingly used for research; however important anamnestic details may be missing from medical records. We compared physician documentation of paediatric exercise-induced respiratory symptoms in clinical notes with parental questionnaire responses for the same children.

Methods: We analysed data from the Swiss Paediatric Airway Cohort (SPAC), a multicentre observational study of children treated in Swiss outpatient pulmonology clinics.

Cohort profile: pulmonary early assessment of the lung in paediatric cancer patients (SWISS-PEARL Study).

Background: Due to the limited sensitivity of conventional lung function tests in detecting small airway abnormalities, cancer treatment-related pulmonary toxicity may be underdiagnosed. It has been suggested that the nitrogen multiple-breath washout test (N2MBW) might be more sensitive in detecting small airway abnormalities in childhood cancer survivors.

Objective: The Pulmonary Early Assessment of the Lung in Paediatric Cancer Patients (SWISS-PEARL) study aims to assess the prevalence and development of early pulmonary toxicity at baseline and longitudinally in paediatric cancer patients using spirometry, body plethysmography, diffusing capacity for carbon monoxide (DLCO), N2MBW and magnetic resonance imaging (MRI) and to identify treatment-related pulmotoxic risk factors.

Evaluating growth references used in Switzerland: a comparative analysis in Zurich schoolchildren.

Introduction: The Swiss Society of Paediatrics currently recommends the growth references of the World Health Organization (WHO), while the Paediatric Endocrinology Centre Zurich (PEZZ) has proposed alternative growth references. Specialists and researchers also use International Obesity Task Force (IOTF) references to define overweight and obesity. We investigated the fit of anthropometric measurements from schoolchildren in the canton of Zurich to these three growth references and assessed the prevalence of overweight, obesity and short stature across the three references.

Prognosis of Breast Cancer in European female adolescents and young adults (AYAs): EUROCARE-6 retrospective cohort results.

Background: Breast cancer (BC) is the most common malignancy in AYA (15-39 years) females and is more aggressive than in adult women (40-69 years). However, an updated overview on BC in AYAs and how it differs from BC in adult women is lacking.

Methods: We used data from the EUROCARE-6 study to calculate incidence rates (IRs) of BC in AYA and adult women over the period 2001-2013 in Europe.

A Health Service Research Study on a Low-Threshold Hearing Screening Program for Childhood Cancer Survivors in Switzerland: Protocol for the HEAR Study.

Background: Hearing loss is a common late effect in childhood cancer survivors, caused by ototoxic cancer treatments, such as platinum chemotherapy, cranial radiation with doses of ≥30 Gray, and surgery involving the auditory system. Early recognition of hearing loss as part of follow-up care allows for therapeutic support to mitigate consequences. However, hearing tests are usually only repeated in childhood cancer survivors with abnormal hearing during or right after treatment ends, leaving hearing loss undetected in childhood cancer survivors with late onset or when missed during cancer treatment.

Assessing Pulmonary Function in Children and Adolescents After Cancer Treatment: Protocol for a Multicenter Cohort Study (Swiss Childhood Cancer Survivor Study FollowUp-Pulmo).

Background: Childhood cancer survivors (CCS) are at risk of pulmonary dysfunction due to cancer treatments, but evidence on prevalence and risk factors remains limited. Most previous studies had small sample sizes or retrospective study designs, little information about treatments, or a lack of standardization of pulmonary function tests (PFTs) or limited their investigation to certain PFTs. Since spirometry mainly assesses the large airways but cancer therapy also affects peripheral airways, additional functional tests are needed.

Awareness about the risk of hearing loss after ototoxic treatments in Swiss childhood cancer survivors.

Objectives: The International Guideline Harmonization Group recommends childhood cancer survivors (CCS) exposed to ototoxic treatments be aware of the risk of hearing loss. We assessed awareness among adult CCS.

Methods: We identified adults diagnosed with cancer < 20 years who received ototoxic treatments through the Swiss Childhood Cancer Registry (ChCR) and invited them to the HEAR-study.

Dental Health of Childhood Cancer Survivors-A Report From the Swiss Childhood Cancer Survivor Study (SCCSS).

Background: Cancer and its treatments can affect dental health of childhood cancer survivors. We aimed to evaluate the prevalence of dental problems in survivors, compare them to their siblings, and investigate cancer-related risk factors.

Methods: As part of the population-based Swiss Childhood Cancer Survivor Study, we sent questionnaires inquiring about dental problems to survivors aged 5-19 years and their siblings.

Diagnosis in Children With Prolonged or Recurrent Cough: Findings From the Swiss Paediatric Airway Cohort.

Introduction: Prolonged or recurrent cough is a common reason for referral to pediatric pulmonologists, yet few studies have assessed its causes. We examined records of children visiting respiratory outpatient clinics in Switzerland and assessed how diagnoses vary by age.

Methods: We analyzed data from the multicenter Swiss Paediatric Airway Cohort study.

Nitrogen single and multiple breath washout test and lung imaging to detect treatment-related pulmonary toxicity in paediatric cancer patients and survivors: a systematic review.

Background: Spirometry-based assessment of pulmonary function has limitations in detecting pulmonary toxicity following cancer treatment with chemotherapy, haematopoietic stem cell transplantation, radiotherapy or thoracic surgery. Nitrogen single and multiple breath washout tests are sensitive in assessing peripheral airway function, and lung imaging detects structural abnormalities, but little is known about their use in paediatric cancer patients and survivors. We aimed to 1) identify studies using nitrogen single or multiple breath washout tests and/or lung imaging to assess pulmonary toxicity in paediatric cancer patients and survivors, and 2) describe reported abnormalities.

Sociodemographic and regional differences in neonatal and infant mortality in Switzerland in 2011-2018: the Swiss National Cohort.

Background And Aims: Despite a well-funded healthcare system with universal insurance coverage, Switzerland has one of the highest neonatal and infant mortality rates among high-income countries. Identifying avoidable risk factors targeted by evidence-based policies is a public health priority. We describe neonatal and infant mortality in Switzerland from 2011 to 2018 and explore associations with neonatal- and pregnancy-related variables, parental sociodemographic information, regional factors and socioeconomic position (SEP) using data from a long-term nationwide cohort study.

Reduced Lower Body Muscular Strength and Endurance among Adult Survivors of Childhood Cancer.

Introduction: Impaired physical fitness is a possible late effect among adult survivors of childhood cancer (ASCC). Our study describes lower body muscular strength and endurance among ASCC using the 1-min sit-to-stand (1-min STS) test, compares them with the general population, identifies risk factors, and describes changes over time.

Methods: In a prospective multicenter cohort study, we invited ASCC ≥18 yr of age at study who were diagnosed between ages 0 and 20 yr, treated in five pediatric oncology centers across Switzerland from 1976 to 2017, and survived ≥5 yr for a 1-min STS test.

Paediatric Personalized Research Network Switzerland (SwissPedHealth): a joint paediatric national data stream.

Introduction: Children represent a large and vulnerable patient group. However, the evidence base for most paediatric diagnostic and therapeutic procedures remains limited or is often inferred from adults. There is an urgency to improve paediatric healthcare provision based on real-world evidence generation.

Psychological distress in adults after pediatric kidney replacement therapy.

Background: There is limited information about psychological distress in adults who underwent kidney replacement therapy (KRT) during childhood. This study aimed to describe psychological distress in adults after KRT during childhood in comparison to the Swiss general population and to evaluate associations with sociodemographic and clinical characteristics.

Methods: We sent a questionnaire to 143 people from the Swiss Pediatric Renal Registry (SPRR), who were alive, over 18 years old, started KRT before the age of 18 years, and were German speakers.

Questionnaire-assessed genotypes and associations with symptoms in primary ciliary dyskinesia.

https://bit.ly/4bvKW4R.

Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis.

Objectives: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study.

Design: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined.

Setting: Children aged 0-18 years from 26 European birth cohorts.