Publications by authors named "Claudia Calderaio"
CAR-T cell therapy for breast cancer: Current status and future perspective.
Cancer Treat Rev
February 2025
Within the expanding therapeutic landscape for breast cancer (BC), metastatic breast cancer (MBC) remains virtually incurable and tend to develop resistance to conventional treatments ultimately leading to metastatic progression and death. Cellular immunotherapy (CI), particularly chimeric antigen receptor-engineered T (CAR-T) cells, has emerged as a promising approach for addressing this challenge. In the wake of their striking efficacy against hematological cancers, CAR-T cells have also been used where the clinical need is greatest - in patients with aggressive BCs.
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- New drugs targeting HER2-positive metastatic breast cancer have shown significant improvements in survival rates, but patients with brain metastases face poorer outcomes compared to those with other types of metastases.
- The prevention and treatment of brain metastasis are critical challenges that need to be addressed to enhance the quality of life and survival for these patients.
- The review explores the causes of brain metastasis, current treatment options, and prospective strategies for future therapies and diagnostics.
Obesity and metabolic disorders have been associated with poor outcomes in non-Mediterranean breast cancer (BC) patients. The purpose of this study was to investigate the prognostic potential of anthropometric variables in patients with early BC living in Southern Mediterranean region of Italy. We enrolled 955 consecutive early BC patients treated in hospitals in Naples between 2009 and 2013 (median follow-up 11.
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