Potential role of avibactam in restoring susceptibility in Escherichia coli with two copies of bla and PBP3 mutations.

Unlabelled: The emergence of carbapenemase-producing represents a significant clinical challenge. Resistance mechanisms involve carbapenemase production, porin and efflux pump alterations, penicillin-binding protein (PBP) modifications, and biofilm formation. This study characterizes a KPC- and a concurrent isolate harboring the same resistance genes, with also exhibiting PBP3 mutations.

Ischaemic Stroke Occurring in a Patient Treated with Monoclonal Antibodies for COVID-19.

Since the COVID-19 outbreak began, an association between COVID-19 and thrombotic diseases has been underlined. Although this association is more frequent with venous thromboembolism, ischaemic stroke has also been reported as a thrombotic complication in several cohorts of affected patients. Furthermore, the association between ischaemic stroke and COVID-19 has been considered a risk factor for early mortality.