Publications by authors named "Chun-Ming Fan"
Background: Phenylalanine accumulation is associated with inflammation, immune system activation, and oxidative stress-all of which are involved in the pathophysiology of acute respiratory distress syndrome (ARDS). This study evaluated the correlation between longitudinal changes in plasma phenylalanine levels and clinical outcomes in patients with ARDS.
Methods: This prospective observational cohort study conducted in Taiwan focused on plasma amino acid profiling in ARDS patients between February 2017 and June 2018, and again between November 2021 and October 2023.
The coming of the hyper-aged society in Taiwan prompts us to investigate the relationship between the metabolic status of sarcopenic patients and their most adverse outcome-death. We studied the association between any plasma metabolites and the risk for mortality among older Taiwanese sarcopenic patients. We applied a targeted metabolomic approach to study the plasma metabolites of adults aged ≥65 years, and identified the metabolic signature predictive of the mortality of sarcopenic patients who died within a 5.
View Article and Find Full Text PDFBackground: Sarcopenia is defined as the disease of muscle loss and dysfunction. The prevalence of sarcopenia is strongly age-dependent. It could bring about disability, hospitalization, and mortality.
View Article and Find Full Text PDFAlterations in lipid composition and disturbed lipoprotein metabolism are involved in the pathomechanism of Huntington's disease (HD). Here, we measured 112 lipoprotein subfractions and components in the plasma of 20 normal controls, 24 symptomatic (sympHD) and 9 presymptomatic (preHD) HD patients. Significant changes were found in 30 lipoprotein subfractions and components in all HD patients.
View Article and Find Full Text PDFArticle Synopsis
- ARDS is a serious condition characterized by an imbalanced immune response, leading to severe oxidative stress and high mortality rates; a study found that over half (52.2%) of patients died in the hospital.
- Researchers assessed amino acid and biogenic amine metabolites in 69 ARDS patients, discovering that higher levels of kynurenine and its ratio to tryptophan in the blood were linked to death rates.
- The study suggests that monitoring the kynurenine pathway could help predict outcomes for ARDS patients and may provide targets for treatments aimed at reducing oxidative stress and improving survival.
Background: Both hepatitis C virus (HCV) infection and adiponectin are critically involved in metabolism. The reversal and associations of altering adiponectin levels after sustained virological responses (SVRs) following direct-acting antivirals (DAA) in HCV-infected patients remained elusive.
Methods: A joint study was conducted in a prospective cohort of 427 HCV-infected patients and a line of HCV core transgenic mice.
Background: How hepatitis C virus (HCV)-associated lipid metabolic alterations recover after sustained virological response (SVR) remains elusive.
Objective: The aforementioned recovery pattern was investigated.
Methods: In a prospective cohort study of 438 chronic hepatitis C (CHC) patients with SVR after anti-HCV therapy, 164 sex- and age-matched genotype I (G1) and G2 patients underwent paired-serum liquid chromatography-tandem mass spectrometry analyses before and 24 weeks after therapy.
Objective: Metabolic syndrome is a multiplex disorder and puts patients on the road to type 2 diabetes and atherosclerotic cardiovascular diseases. However, a surrogate biomarker in plasma or urine in fully reflecting features of metabolic syndrome has not been explored.
Research Design And Methods: Urine metabolomics has potential utility in metabolic profiling because urine metabolites analysis reflects global outflux of metabolic change.