A comprehensive review of 30 years of pediatric clinical trial radiotherapy dose constraints.

Background: Radiation therapy normal tissue dose constraints are critical when treating pediatric patients. However, there is limited evidence supporting proposed constraints, which has led to variations in constraints over the years. In this study, we identify these variations in dose constraints within pediatric trials both in the United States and in Europe used in the past 30 years.

Volumetric modulated craniospinal irradiation workflow optimization through quantitative analytics: a single-institution case study comparing pediatric and adult settings.

Objective: We used quantitative analytics to assess the efficiency of the clinical workflow for radiation therapy delivery in children and adults focusing on our experience with volumetric modulated arc therapy (VMAT) craniospinal irradiation (CSI).

Methods: We retrospectively collected clinical and treatment specific data between June 2013 and November 2018 for 614 VMAT CSI sessions of 41 pediatric patients and 48 VMAT CSI sessions of 6 adult patients treated at two hospitals within the same academic institution. Descriptive statistics were generated and a multiple linear regression model was created to predict total radiation time (TRT) based on these predictors.