Publications by authors named "Ching-Chang Chen"

Pre-operative stage embolization is a valuable strategy for managing large arteriovenous malformations (AVMs). However, reflux of Onyx may be out of control and cause accidental embolization at the feeding artery's opening. We report a case of 27-year-old male suffering from right occipital AVM bleeding with left hemianopia.

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Background: Blood blister-like aneurysms (BBAs) of the internal carotid artery are rare but high risk lesions that frequently re-rupture due to their fragile structure and dissecting pathology. Treatment is particularly challenging in ruptured cases, given the risks associated with dual antiplatelet therapy. Recent advancements in flow diverter stents (FDSs) with surface modifications, and the use of single antiplatelet therapy (SAPT), offer a potential alternative strategy.

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BackgroundThrombocytopenia leads to increased postoperative complications and mortality in elective surgeries.Questions/purposesSpecific roles of thrombocytopenia on outcomes in orthopedic surgery remain relatively unexplored. This study aimed to assess the impact of chronic thrombocytopenia on outcomes of metastatic spinal tumor surgery.

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Functional recovery after minimally invasive surgery for intracerebral hemorrhage (ICH) varies. In this study, we introduce a novel robot-assisted stereotactic aspiration and lysis procedure to evacuate deep-seated ICH and evaluate the efficiency of improving neurologic outcomes. Adult patients with spontaneous ICH less than 40 mL were prospectively recruited and underwent a novel protocol combining aspiration and lysis through a single trajectory planned and executed with a neurosurgical robot.

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Introduction: While angioembolization is occasionally required for craniofacial fracture patients who experience massive maxillofacial hemorrhage, complications such as headache, temporal-facial pain, soft tissue necrosis, and embolic material migration leading to stroke or blindness can arise. Few studies have explored delayed or progressive intracerebral hemorrhage (ICH) following angioembolization for craniofacial fractures.

Methods: A retrospective review of craniofacial fracture patients from January 1, 2015, to December 31, 2022 at our institution was conducted.

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Rationale: Blunt traumatic arteriovenous fistula (AVF) of scalp, are uncommon and most of them can be secured by simple embolization or surgical ligation of the feeders. Our goal in writing this paper is to show patients with traumatic scalp AVFs how to prevent complications and the likelihood of recurrence.

Patient Concerns: Complete treatment and reduce the recurrence rate of traumatic AVF on the scalp.

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Background: Blunt cerebrovascular injury (BCVI) accounts for 1-3 % of patients with blunt trauma, which should be promptly diagnosed and managed due to risk of cerebral infarction and death. Antithrombotic therapy had been proven to reduce risk of stroke and mortality. However, due to concern of hematoma progression, treatment suggestion is still inconclusive for patients with concurrent traumatic intracranial hemorrhage.

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Article Synopsis
  • - This study explores using the C1 nerve root as a key surgical guide for identifying the shunting point of craniocervical junction spinal dural arteriovenous fistulas (CCJ-SDAVF) during surgery, based on data from 7 patients treated from January 2017 to June 2023.
  • - Of the 7 patients, most (71.4%) were male, and all showed complete obliteration of the CCJ-SDAVFs post-surgery, with follow-up assessments revealing no recurrences within two years.
  • - The findings suggest that interrupting CCJ-SDAVFs surgically yields high success rates and good functional recovery for most patients, emphasizing the importance of identifying the C1 nerve
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Background: Chronic subdural hematoma (CSDH) is a prevalent neurosurgical condition that is known to recur and that leads to unfavorable clinical outcomes. Middle meningeal artery embolization (MMAE) has emerged as an alternative treatment to prevent recurrence. This study investigated the efficacy of combined 2 therapies in a hybrid operative suite for high-risk patients.

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  • This study investigated how different doses of tissue plasminogen activator (tPA) influence treatment outcomes in patients undergoing mechanical thrombectomy (MT) for stroke, particularly looking at standard (within 6 hours) and extended (after 6 hours) treatment windows.
  • It was found that in the standard window, patients receiving full-dose tPA had significantly better functional outcomes after 90 days compared to those receiving a reduced dose (49% vs 21%).
  • Conversely, in the extended window, the dosage of tPA (full vs reduced) did not impact functional outcomes, suggesting that the timing of the treatment is more critical than the tPA dosage in these cases.
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Objective: Incomplete occlusion of cerebral dural arteriovenous fistula (DAVF) may lead to fistula recurrence and rebleeding, which may necessitate several embolizations and lead to worse clinical outcomes. Herein, we describe a grouting technique for endovascular embolization and its outcomes in a series of patients with complex intracranial DAVF.

Methods: A total of 20 patients with aggressive type or symptomatic intracranial non-cavernous DAVF underwent endovascular transvenous embolization combining detachable coils and Onyx.

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  • * Researchers divided the sTBI patients into three groups based on disability severity using the Modified Rankin Score, analyzing the relationship between biomarker levels and patient outcomes over the week following the injury.
  • * Findings showed that elevated levels of specific cytokines, particularly IL-6, were associated with different outcomes among the patient groups, indicating their potential use in predicting recovery or decline in sTBI cases.
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  • Ethmoidal dural arteriovenous fistulas (DAVFs) are rare and serious brain lesions that can lead to bleeding and neurological issues due to their unique drainage patterns.
  • Surgical methods generally have fewer complications and better success rates in resolving DAVFs compared to endovascular treatments.
  • The supraorbital keyhole subfrontal approach is highlighted as a minimally invasive and effective surgical technique for treating these types of brain lesions, as demonstrated by two patients who achieved successful outcomes.
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Introduction: Patients with subdural hemorrhage (SDH) and a Glasgow Coma Scale (GCS) score of 13-15 are typically categorized as having mild traumatic brain injury. We hypothesize that patients without a maximum GCS score - specifically, patients with GCS scores of 13 and 14 - may exhibit poorer neurological outcomes.

Method: Between January 1, 2019, and December 31, 2020, SDH patients with GCS scores ranging from 13 to 15 were retrospectively studied.

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  • A study evaluated a new portable neuroendoscopic system for minimally invasive surgery to remove spontaneous intracerebral hemorrhages, showing promising outcomes in a small group of ten patients.
  • The system allowed for improved surgical precision and efficiency, resulting in an 86% reduction in hematoma volume within 6 hours post-surgery and significant improvement in patient recovery scores.
  • No deaths or complications like rebleeding occurred in the follow-up period, indicating the device's potential, but further research is necessary to understand its long-term benefits.
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Background: Programmable valve (PV) has been shown as a solution to the high revision rate in pediatric hydrocephalus patients, but it remains controversial among adults. This study is to compare the overall revision rate, revision cause, and revision-free survival between PV and non-programmable valve (NPV) in adult patients with different hydrocephalus etiologies.

Method: We reviewed the chart of all patients with hydrocephalus receiving index ventricular cerebrospinal fluid (CSF) shunt operations conducted at a single institution from January 2017 to December 2017.

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  • * Out of 112 patients analyzed, the research found that 13.4% experienced recurrence, predominantly among those treated without stents, and aneurysm rupture was a significant risk factor for recurrence.
  • * The findings revealed that aneurysms treated with stent-assisted coiling had better long-term outcomes, as no re-recurrence was noted in patients undergoing this method after an initial recurrence.
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Objective: Continuous cardiac monitoring on patients with aneurysmal subarachnoid hemorrhage (aSAH) is difficult out of intensive care unit (ICU) in the subacute stage. Therefore, we verified the feasibility of a novel electrocardiography (ECG) patch device to record long-term heart rhythm.

Methods: The ECG patches were applied on aSAH patients during their stay in general ward.

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Purpose: Creating enough decompression, favorable outcome, less complication, and maintain adequate lordosis and stability in the patients with cervical myelopathy due to multilevel massive ossification of the posterior longitudinal ligament (OPLL) still poses a challenge for surgeons. The aim of our study is to retrospectively evaluate our patients and try to seek a better surgical strategy.

Methods: Between 2015 and 2019, 55 consecutive patients with multilevel massive OPLL underwent surgical treatment.

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Background: Traumatic brain injury (TBI) patients with unconsciousness and normal initial head computed tomography (CT) present a clinical dilemma for physicians and neurosurgeons in the emergency department (ED). We recorded how long it took for patients to regain consciousness and evaluated the patients' characteristics.

Methods: From 2018 to 2020, TBI patients with unconsciousness and normal initial head CT [Glasgow coma scale (GCS) score < 13, negative CT scan and normal laboratory test results] were evaluated.

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Objective: Laparoscopic ventriculoperitoneal shunt surgery has been reported to have several advantages in selected patients. However, the prognostic factors have been understudied specifically for this surgery. We sought to investigate the factors influencing the complications after the laparoscopic ventriculoperitoneal shunt placement.

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  • The study investigates delayed progressive mass effect (DPME) following treatment of ruptured middle cerebral artery (MCA) aneurysms, noting its association with poor clinical outcomes and the possible need for additional surgical intervention.
  • Out of 80 patients studied, 27 (33.7%) experienced DPME, which significantly correlated with a higher likelihood of requiring salvage surgery and worse 90-day functional outcomes.
  • Independent risk factors for DPME included the presence of hematomas, CTA spot signs, and low-density areas in the perisylvian region, highlighting the importance of monitoring these factors post-operation.
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Background: Spinal cord injury (SCI) and spinal fracture are major complications in patients with ankylosing spondylitis (AS) who sustain spinal trauma. The purpose of this study was to investigate the incidence, predictors, and sequelae of spinal trauma in patients with AS.

Methods: This retrospective study included patients with AS who were admitted for spinal trauma between January 1, 2006, and June 30, 2016.

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  • Traumatic intraventricular hemorrhage (tIVH) significantly increases in-hospital mortality (11.4% vs. 9.2%) and the chances of poor functional outcomes (37.9% vs. 10.6%) in traumatic brain injury (TBI) patients.
  • A study of 5048 TBI patients over five years identified 149 with tIVH and utilized inverse probability of treatment weighting to minimize confounding variables.
  • Key factors affecting outcomes included age (especially those 65 and older), Glasgow Coma Scale scores, and a new scoring system called the Traumatic Graeb Score, where a score of 4 or higher indicates worse functional outcomes.
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To restore lost functions while repairing the neuronal structure after spinal cord injury (SCI), pharmacological interventions with multiple therapeutic agents will be a more effective modality given the complex pathophysiology of acute SCI. Toward this end, we prepared electrospun membranes containing aligned core-shell fibers with a polylactic acid (PLA) shell, and docosahexaenoic acid (DHA) or a brain-derived neurotropic factor (BDNF) in the core. The controlled release of both pro-regenerative agents is expected to provide combinatory treatment efficacy for effective neurogenesis, while aligned fiber topography is expected to guide directional neurite extension.

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