Publications by authors named "Chineye D Emeche"
Chemokines mediate the signaling and migration of T cells, but little is known about the transcriptional events involved therein. Microarray analysis of CXC chemokine ligand (CXCL) 12-treated T cells revealed that Wnt ligands are significantly up-regulated during CXCL12 treatment. Real-time polymerase chain reaction and Western blot analysis confirmed that the expression of noncanonical Wnt pathway members (eg, Wnt5A) was specifically up-regulated during CXCL12 stimulation, whereas beta-catenin and canonical Wnt family members were selectively down-regulated.
View Article and Find Full Text PDFArticle Synopsis
- There are no effective treatments for metastatic melanoma, and targeted immunotherapy is only successful in a small fraction of cases.
- This study reveals that the noncanonical Wnt ligand Wnt5A can promote melanoma metastasis and suppress key tumor-associated antigens needed for effective immune responses.
- The research indicates that manipulating Wnt5A levels could improve the response to immunotherapy by increasing tumor-associated antigen expression and CTL activation in patients with metastatic melanoma.