[Current status and challenges in the utilization of information and communication technology and digitalization in public health nursing activities: A national survey of supervisory public health nurses in local governments].

Objectives　To understand the current conditions and challenges in the utilization and digitalization of information and communication technology (ICT) in public health nursing, using a nationwide survey of local government public health nurses. The study also seeks to provide recommendations for enhancing the utilization of ICT in public health nursing.Methods　An online, anonymous, and self-administered survey of public health nurses in supervisory positions across 47 prefectures and 1,741 municipalities was conducted.

Enantioselective One-Pot Synthesis of Cyclopropane-Fused Tetrahydroquinolines via a Ru-Catalyzed Intramolecular Cyclopropanation.

A highly enantioselective one-pot synthesis of cyclopropane-fused tetrahydroquinolines bearing carbonyl functionalities, which are difficult to synthesize using conventional methods, is reported. Employing readily accessible alkene-tethered anthranilaldehydes, hydrazone formation and subsequent Ru-catalyzed intramolecular cyclopropanation furnish the desired products in ≤87% yield and ≤95% ee under mild conditions. Various anthranilaldehydes, functionalized alkenes, and -aryl sulfonyl groups are tolerated, and a series of synthetic transformations were conducted to demonstrate the practical utility.

Coregulation of () and () gene expression in Arabidopsis roots in response to ammonium supply.

Ammonium absorbed by roots is assimilated into amino acids. The glutamine synthetase/glutamate synthase (glutamine 2-oxoglutarate aminotransferase) (GS/GOGAT) cycle is essential to this biological process. In , and are the and isoenzymes induced in response to ammonium supply and playing key roles in ammonium utilization.

Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production.

Amyloid-β peptides (Aβs) are produced via cleavage of the transmembrane region of the amyloid precursor protein (APP) by γ-secretase and are responsible for Alzheimer's disease. Familial Alzheimer's disease (FAD) is associated with APP mutations that disrupt the cleavage reaction and increase the production of neurotoxic Aβs, i.e.

Supplemental Clostridium butyricum MIYAIRI 588 Affects Intestinal Bacterial Composition of Finishing Pigs.

Animal gastrointestinal tracts are populated by highly diverse and complex microbiotas. The gut microbiota influences the bioavailability of dietary components and is closely associated with physiological processes in the host. Clostridium butyricum reportedly improves growth performance and affects the gut microbiota and immune functions in post-weaning piglets.

Specific Mutations in Aph1 Cause γ-Secretase Activation.

Amyloid beta peptides (Aβs) are generated from amyloid precursor protein (APP) through multiple cleavage steps mediated by γ-secretase, including endoproteolysis and carboxypeptidase-like trimming. The generation of neurotoxic Aβ42/43 species is enhanced by familial Alzheimer's disease (FAD) mutations within the catalytic subunit of γ-secretase, presenilin 1 (PS1). FAD mutations of PS1 cause partial loss-of-function and decrease the cleavage activity.

Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid β trimming.

γ-Secretase generates amyloid beta peptides (Aβ) from amyloid precursor protein through multistep cleavages, such as endoproteolysis (ε-cleavage) and trimming (γ-cleavage). Familial Alzheimer's disease (FAD) mutations within the catalytic subunit protein of presenilin 1 (PS1) decrease γ-cleavage, resulting in the generation of toxic, long Aβs. Reducing long Aβ levels has been proposed as an AD therapeutic strategy.

Compared effects of calcium and sodium polystyrene sulfonate on mineral and bone metabolism and volume overload in pre-dialysis patients with hyperkalemia.

Background: Hyperkalemia is prevalent in end-stage renal disease patients, being involved in life-threatening arrhythmias. Although polystyrene sulfonate (PS) is commonly used for the treatment of hyperkalemia, direct comparison of effects between calcium and sodium PS (CPS and SPS) on mineral and bone metabolism has not yet been studied.

Methods: In a randomized and crossover design, 20 pre-dialysis patients with hyperkalemia (>5 mmol/l) received either oral CPS or SPS therapy for 4 weeks.

Glutamate promotes nucleotide synthesis in the gut and improves availability of soybean meal feed in rainbow trout.

Glutamate (Glu) plays various roles directly or through conversions to other amino acids in intracellular metabolisms such as energy source for enterocytes and precursor for nucleic acids. In this study, we examined the effect of single and chronic oral administration of Glu on cell proliferation in intestine and growth in rainbow trout fed soybean meal (SBM) based diet. In the single dose study, 30, 120 and 360 min after oral administration of 50 and 500 mg/kg Glu, the blood and intestine tissues were collected for amino acid concentration and gene expression analysis.

Early nocturnal meal skipping alters the peripheral clock and increases lipogenesis in mice.

Background: In humans, skipping meals, especially breakfast, has been associated with obesity and other related syndromes. Recent studies in rodents suggest that fasting and feeding times are potential factors that affect the peripheral circadian clocks and metabolism. However, the link between fasting and obesity in rodents has yet to be fully demonstrated.

Ratio of directly necrotized volume to total volume of a submucosal myoma predicts shrinkage after microwave endometrial ablation.

Aim: To explore parameters relating to shrinkage of submucosal myomas after microwave endometrial ablation.

Methods: Fourteen patients underwent microwave endometrial ablation at 2.45 GHz using a curved microwave applicator to treat menorrhagia caused by a submucosal myoma.

A scoring system for histopathologic and immunohistochemical evaluations of uterine leiomyosarcomas.

Uterine leiomyosarcomas (LMS) are difficult to distinguish from benign leiomyomas without surgery. In this study we performed transcervical needle biopsy on 475 patients, 8 LMS patients and 467 patients with non-sarcomas (non-LMS) in a high-risk group for LMS, and evaluated whether examinations performed with Ki-67 and CD34 immunohistochemical analyses in addition to the standard hematoxylin-eosin (H&E)-stained sections would improve preoperative diagnostic precision of the uterine smooth muscle tumors. Histopathologic analysis included three factors: degree of cytologic atypia, mitotic index and coagulative tumor cell necrosis (CTCN).

Transcervical microwave myolysis for uterine myomas assisted by transvaginal ultrasonic guidance.

Aim: The effects of transcervical microwave myolysis at 2.45 GHz after microwave endometrial ablation for menorrhagia were examined in patients with myomas.

Methods: A transcervical microwave irradiation system assisted by transvaginal ultrasonic guidance was developed.

Expression of glucose transporters in epithelial ovarian carcinoma: correlation with clinical characteristics and tumor angiogenesis.

We immunohistochemically examined the expression of the glucose transporters (GLUT)1, GLUT3 and GLUT4, in 154 tumor samples of epithelial ovarian carcinoma. In addition, we investigated the correlations between the expression of GLUTs and the vascular endothelial growth factor (VEGF), and microvessel count and clinical parameters. The rates of expression of GLUT1, GLUT3 and GLUT4 were 98.