Publications by authors named "Chia-Hsuan Cheng"

Correction for 'Utilizing layer-parameter of shear horizontal surface acoustic wave biosensor for lipoprotein particle sizing' by Chia-Hsuan Cheng , , 2025, https://doi.org/10.1039/d5lc00444f.

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Large EVs () and small EVs () are distinct extracellular vesicles (EVs) found in physiological fluids with different size ranges, biogenesis pathways, and biomarker cargoes. This study introduces a novel approach using a shear horizontal surface acoustic wave (SH-SAW) biosensor to estimate the composition independently of EV concentration and interfering agents. A layer parameter, corresponding to the ratio of amplitude attenuation to velocity fractional change, is shown to be linearly correlated with the median EV size.

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Shear horizontal surface acoustic wave (SH-SAW) sensors are widely used in biosensing for marker detection and can also measure particle size. This study leverages SH-SAW technology with a reflective-type design and unique packaging technology to distinguish lipoprotein sizes on a 3 × 5 mm sensor chip, addressing the limitations of traditional, time-consuming methods like chromatography and nuclear magnetic resonance (NMR). A 250 MHz SH-SAW biosensor on 36° rotated Y-cut 90° X-propagating quartz substrates was used, with ApoA1, ApoB48, ApoB100, and Lp(a) antibodies immobilized on a gold surface to capture lipoproteins from human plasma.

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Cardiovascular disease (CVD) represents the leading cause of death worldwide. For individuals at elevated risk for cardiovascular disease, early detection and monitoring of lipid status is imperative. The majority of lipid measurements conducted in hospital settings employ optical detection, which necessitates the use of relatively large-sized detection machines.

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Atherosclerosis is an inflammatory disease of the arteries associated with alterations in lipid and other metabolism and is a major cause of cardiovascular disease (CVD). LDL consists of several subclasses with different sizes, densities, and physicochemical compositions. Small dense LDL (sd-LDL) is a subclass of LDL.

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Point-of-care testing (POCT), also known as on-site or near-patient testing, has been exploding in the last 20 years. A favorable POCT device requires minimal sample handling (e.g.

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To prevent the COVID-19 pandemic that threatens human health, vaccination has become a useful and necessary tool in the response to the pandemic. The vaccine not only induces antibodies in the body, but may also cause adverse effects such as fatigue, muscle pain, blood clots, and myocarditis, especially in patients with chronic disease. To reduce unnecessary vaccinations, it is becoming increasingly important to monitor the amount of anti-SARS-CoV-2 S protein antibodies prior to vaccination.

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Since the Coronavirus disease 2019 (COVID-19) pandemic outbreak, many methods have been used to detect antigens or antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including viral culture, nucleic acid test, and immunoassay. The shear-horizontal surface acoustic wave (SH-SAW) biosensor is a novel pathogen detection platform with the advantages of high sensitivity and short detection time. The objective of this study is to develop a SH-SAW biosensor to detect the anti-SARS-CoV-2 nucleocapsid antibody.

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