Publications by authors named "Chia-Che Chiang"

Thrombosis presents a critical health threat globally, with high mortality and incidence rates. Clinical treatment faces challenges such as low thrombolytic agent bioavailability, thrombosis recurrence, ischemic hypoxia damage, and neural degeneration. This study developed biocompatible Chlamydomonas Reinhardtii micromotors (CHL) with photo/magnetic capabilities to address these needs.

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  • Thrombotic cardiovascular diseases can cause serious health problems and even death.
  • A new treatment called SPCS uses tiny swimming cells to help break up blood clots and reduce damage to affected areas.
  • This method has shown great results in mice, helping deliver medicine more effectively and improving recovery from health issues caused by blood clots.
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  • A new treatment for vascular blockages has been created to improve upon existing thrombolytic therapies, using a specialized nano-propeller technology that includes iron oxide and offers both fluorescent and magnetic properties.
  • This innovative platform can be guided to target blood clots with precision and can be activated using near-infrared light and magnetotherapy.
  • In tests on mice with thrombus lesions, this multi-faceted approach demonstrated about an 80% reduction in blood clot residues, suggesting it significantly enhances both the effectiveness and speed of thrombolytic therapy.
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  • Thrombosis is a serious issue due to high mortality and recurrence rates, prompting the need for better antithrombotic strategies; current noninvasive treatments face challenges like low targeting efficiency and rapid half-life.
  • A new technology using cotton-ball-shaped platelet-mimetic nanomotors, engineered with a phototherapeutic platform, has been developed to deliver a synthetic peptide to thrombus sites, enabling more effective site-specific thrombolysis.
  • The P6@PEDOT@PLT nanomotors, activated by near-infrared light, show improved penetration of thrombus lesions and enhanced treatment effectiveness, potentially restoring vascular health and preventing rethrombosis.
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Thrombolytic and antithrombotic therapies are limited by short circulation time and the risk of off-target hemorrhage. Integrating a thrombus-homing strategy with photothermal therapy are proposed to address these limitations. Using glycol chitosan, polypyrrole, iron oxide and heparin, biomimicking GCPIH nanoparticles are developed for targeted thrombus delivery and thrombolysis.

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Passivation of surface states is known to reduce the onset photocurrent potential by removing the Fermi level pinning effect at the Helmholtz layer and enhance the photocurrent plateau by suppressing recombination loss in the space charge region. We report for the first time that metal ions can effectively passivate surface states in situ that improves the photoelectrochemical (PEC) performance of hematite electrodes. Among metal ions studied, Cr(iii), Mn(ii), Fe(ii), Co(ii), Cu(ii) and Zn(ii) were found to enhance the photocurrent by 30-300%; whereas photocurrent density significantly dropped by 90% in Ni(ii) solution after 90 min of illumination.

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The elemental content of fish scales is known to be a reliable biogeochemical tag for tracing the origin of fishes. In this study, this correlation is further confirmed to exist on the surface of fish scales using a novel environmental analytical method, laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), which bypasses several complicated sample preparation procedures such as acid digestion and pre-concentration. The results suggest that the elemental ratios of Sr/Ca, Ba/Ca, and Mn/Ca on the surface of fish scales are strongly correlated with the geochemical environment of their original habitat.

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