Mutual boost between free radicals and photothermal effect for synergistic photothermal/thermodynamic antibacterial therapy.

Combined treatment is a promising strategy in antibacterial treatment, which could alleviate the shortcomings of monotherapy and achieve better therapeutic effects. In this work, mutual boost between free radical generation and photothermal effect for synergistic photothermal/thermodynamic antibacterial therapy was reported. Mesoporous silica nanoparticles were used as drug carrier for loading dibenzoyl peroxide (BPO).

Glutathione-depletion reinforced enzyme catalytic activity for photothermal assisted bacterial killing by hollow mesoporous CuO.

The emergence and prevalence of drug-resistant bacteria caused by the overuse of antibiotics pose new challenges to the treatment of bacterial infections. In this work, hollow mesoporous CuO nanozymes (HM-CuO nanozymes) as excellent antibacterial agents were prepared by a template method. The synthesized HM-CuO nanozymes exhibit peroxidase-like catalytic activity, which can efficiently catalyze HO to generate toxic reactive oxygen species (ROS), causing fatal damage to bacteria.