[Retracted] Upregulation of GRIM‑19 suppresses the growth of oral squamous cell carcinoma and .

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the western blot data shown in Figs. 1C and 5C on p. 2186 and p.

Enhanced antitumor effect of cisplatin in human oral squamous cell carcinoma cells by tumor suppressor GRIM‑19.

Gene associated with retinoid‑interferon‑induced mortality 19 (GRIM‑19) is a novel candidate tumor suppressor gene located on the human chromosome 19p13.1 region. Our previous study demonstrated that the upregulation of GRIM‑19 in human oral squamous cell carcinoma (OSCC) cells significantly inhibited tumor cell growth in vitro and in vivo.

Upregulation of GRIM-19 suppresses the growth of oral squamous cell carcinoma in vitro and in vivo.

Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) and its upregulation contribute to the progression and metastasis of several different tumor types. The gene associated with retinoid‑interferon‑induced mortality-19 (GRIM-19) is known to functionally interact with STAT3 and inhibit its transcriptional activity. It has been reported that upregulation of genes associated with GRIM-19 can significantly reduce the tumor growth of several types of tumors.